• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Initial clinical trials in cancer patients of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine, in carboxymethylcellulose [poly(ICLC)], a highly effective interferon inducer.

作者信息

Levine A S, Sivulich M, Wiernik P H, Levy H B

出版信息

Cancer Res. 1979 May;39(5):1645-50.

PMID:371793
Abstract
摘要

相似文献

1
Initial clinical trials in cancer patients of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine, in carboxymethylcellulose [poly(ICLC)], a highly effective interferon inducer.聚肌苷酸-聚胞苷酸与聚-L-赖氨酸稳定结合，并存在于羧甲基纤维素中（聚（ICLC）），这是一种高效的干扰素诱导剂，在癌症患者中进行的初步临床试验。
Cancer Res. 1979 May;39(5):1645-50.
2
Phase I-II trials of poly IC stabilized with poly-L-lysine.聚-L-赖氨酸稳定的聚肌胞苷酸的I-II期试验。
Cancer Treat Rep. 1978 Nov;62(11):1907-12.
3
An Eastern Cooperative Oncology Group phase I-II pilot study of polyriboinosinic-polyribocytidylic acid poly-L-lysine complex in patients with metastatic malignant melanoma.东部肿瘤协作组关于聚肌苷酸-聚胞苷酸聚-L-赖氨酸复合物用于转移性恶性黑色素瘤患者的I-II期初步研究。
J Biol Response Mod. 1985 Dec;4(6):664-8.
4
Interferon induction in primates by stabilized polyriboinosinic acid-polyribocytidylic acid: effect of component size.稳定化聚肌苷酸-聚胞苷酸在灵长类动物中诱导干扰素：组分大小的影响
Infect Immun. 1981 Nov;34(2):416-21. doi: 10.1128/iai.34.2.416-421.1981.
5
Topical polyriboinosinic-polyribocytidylic acid complex in the treatment of recurrent genital herpes.局部应用聚肌苷酸-聚胞苷酸复合物治疗复发性生殖器疱疹。
Antimicrob Agents Chemother. 1982 Mar;21(3):481-5. doi: 10.1128/AAC.21.3.481.
6
A phase I evaluation of poly(I,C)-LC in cancer patients.
J Biol Response Mod. 1985 Dec;4(6):650-5.
7
Modified polyriboinosinic-polyribocytidylic acid complex: induction of serum interferon, fever, and hypotension in rabbits.修饰的聚肌苷酸-聚胞苷酸复合物：对兔血清干扰素、发热及低血压的诱导作用
Antimicrob Agents Chemother. 1980 Jan;17(1):49-54. doi: 10.1128/AAC.17.1.49.
8
Enhanced induction of plasma interferon after subcutaneous administration in rabbits of poly ICLC with albumin.在兔皮下注射聚肌胞苷酸与白蛋白复合物后，血浆干扰素诱导增强。
J Biol Regul Homeost Agents. 1989 Jul-Sep;3(3):118-21.
9
Phase I trials of poly(I,C) complexes in advanced cancer.
J Biol Response Mod. 1985 Dec;4(6):640-9.
10
Phase I-II trials of poly(ICLC) in malignant brain tumor patients.聚肌胞苷酸-聚左旋赖氨酸-羧甲基纤维素（poly(ICLC)）用于恶性脑肿瘤患者的I-II期试验。
J Interferon Res. 1982;2(1):1-4. doi: 10.1089/jir.1982.2.1.

引用本文的文献

1
Targeted apoptotic immune modulator for the treatment of metastatic EGFR-positive solid tumors.用于治疗转移性表皮生长因子受体阳性实体瘤的靶向凋亡免疫调节剂。
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2500489122. doi: 10.1073/pnas.2500489122. Epub 2025 May 29.
2
ARNAX is an ideal adjuvant for COVID-19 vaccines to enhance antigen-specific CD4 and CD8 T-cell responses and neutralizing antibody induction.ARNAX是新冠疫苗增强抗原特异性CD4和CD8 T细胞反应以及诱导中和抗体的理想佐剂。
J Virol. 2025 May 20;99(5):e0229024. doi: 10.1128/jvi.02290-24. Epub 2025 Apr 15.
3
Live attenuated VZV vaccination induces antitumor immunity in ATLL patients.
水痘带状疱疹病毒活疫苗接种可诱导 ATLL 患者产生抗肿瘤免疫。
Cancer Immunol Immunother. 2023 Apr;72(4):929-944. doi: 10.1007/s00262-022-03301-6. Epub 2022 Oct 1.
4
Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy.通过联合放疗靶向DNA损伤反应和模式识别受体来增强抗肿瘤先天免疫。
Front Oncol. 2022 Aug 29;12:971959. doi: 10.3389/fonc.2022.971959. eCollection 2022.
5
Intratumoural immunotherapy: activation of nucleic acid sensing pattern recognition receptors.肿瘤内免疫疗法：核酸传感模式识别受体的激活
Immunooncol Technol. 2019 Oct 16;3:15-23. doi: 10.1016/j.iotech.2019.10.001. eCollection 2019 Oct.
6
Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against .用 CSP 和 RIG-I 激动剂进行免疫接种可有效诱导针对 的功能性和保护性体液免疫应答。
Front Immunol. 2022 May 20;13:868305. doi: 10.3389/fimmu.2022.868305. eCollection 2022.
7
HTLV-1 Tax-specific memory cytotoxic T lymphocytes in long-term survivors of aggressive-type adult T-cell leukemia/lymphoma.抗 HTLV-1 Tax 特异性记忆细胞毒性 T 淋巴细胞在侵袭性成人 T 细胞白血病/淋巴瘤的长期幸存者中。
Cancer Med. 2022 Sep;11(17):3238-3250. doi: 10.1002/cam4.4689. Epub 2022 Mar 22.
8
Activation of Innate Immunity by Therapeutic Nucleic Acids.治疗性核酸激活固有免疫。
Int J Mol Sci. 2021 Dec 12;22(24):13360. doi: 10.3390/ijms222413360.
9
Safety and antibody immune response of CHP-NY-ESO-1 vaccine combined with poly-ICLC in advanced or recurrent esophageal cancer patients.在晚期或复发性食管癌患者中，CHP-NY-ESO-1 疫苗联合 Poly-ICLC 的安全性和抗体免疫应答。
Cancer Immunol Immunother. 2021 Nov;70(11):3081-3091. doi: 10.1007/s00262-021-02892-w. Epub 2021 Mar 22.
10
Immunogenicity and Toxicity of Different Adjuvants Can Be Characterized by Profiling Lung Biomarker Genes After Nasal Immunization.不同佐剂的免疫原性和毒性可通过鼻腔免疫后肺部生物标志物基因的特征来描述。
Front Immunol. 2020 Sep 11;11:2171. doi: 10.3389/fimmu.2020.02171. eCollection 2020.