Department of Radiology, AZ Maria Middelares, Buitenring Sint-Denijs 30, 9000, Ghent, Belgium.
Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Neuroradiology. 2021 Jan;63(1):153-156. doi: 10.1007/s00234-020-02543-4. Epub 2020 Sep 3.
Genetic leukoencephalopathies are inherited disorders characterized by progressive white matter involvement. Although most are paediatric conditions, late-onset adult leukoencephalopathies are being increasingly recognized. Adult leukoencephalopathies may present as neurodegenerative diseases with cognitive decline and motor symptoms. Similar to their paediatric counterparts, different adult leukoencephalopathies often have distinctive MRI appearances. In particular, DWI has been recently shown to demonstrate specific patterns of persistent diffusion restriction in several adult-onset leukoencephalopathies. As such, DWI may provide important clues to the diagnosis of adult-onset leukoencephalopathy. The purpose of this review is to discuss characteristic DWI features in some late-onset leukoencephalopathies.
遗传性脑白质病是一种以进行性白质受累为特征的遗传性疾病。尽管大多数是儿科疾病，但越来越多的成年人脑白质病也被认识到。成人脑白质病可能表现为神经退行性疾病，伴有认知功能下降和运动症状。与儿科患者类似，不同的成人脑白质病通常具有不同的 MRI 表现。特别是，DWI 最近显示，在几种成人起病的脑白质病中存在特定的持续弥散受限模式。因此，DWI 可能为成人起病的脑白质病的诊断提供重要线索。本综述的目的是讨论一些迟发性脑白质病的 DWI 特征。
