State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, P. R. China.
University of Science and Technology of China, Hefei 230026, P. R. China.
ACS Appl Mater Interfaces. 2020 Sep 30;12(39):43456-43465. doi: 10.1021/acsami.0c12824. Epub 2020 Sep 16.
Cancer deaths are mainly caused by tumor metastases. However, tumor ablation therapies can only target the primary tumor but not inhibit tumor metastasis. Herein, a multifunctional covalent organic framework (COF)-based nanocomposite is designed for synergetic photo-, chemodynamic- and immunotherapies. Specifically, the synthesized COF possesses the ability to produce singlet oxygen under the 650 nm laser irradiation. After being metallized with FeCl, -phenylenediamine is polymerized on the surface of COF with Fe as the oxidant. The obtained poly(-phenylenediamine) can be used for photothermal therapy. Meanwhile, the overexpressed HO in the tumor would be further catalyzed and decomposed into hydroxyl radicals (OH) by the Fe/Fe redox couple via Fenton reaction. Intriguingly, the increase of temperature caused by photothermal therapy can accelerate the production of OH. Moreover, the tumor-associated antigen induced a robust antitumor immune response and effectively inhibited tumor metastasis in the presence of anti-PD-L1 checkpoint blockade. Such a COF-based multifunctional nanoplatform provides an efficacious treatment strategy for both the primary tumor and tumor metastasis.
癌症死亡主要是由肿瘤转移引起的。然而，肿瘤消融疗法只能针对原发性肿瘤，而不能抑制肿瘤转移。在此，设计了一种基于多功能共价有机骨架（COF）的纳米复合材料，用于协同光、化学动力学和免疫治疗。具体来说，所合成的 COF 在 650nm 激光照射下具有产生单线态氧的能力。用 FeCl 金属化后，邻苯二胺在 COF 表面聚合，Fe 作为氧化剂。所得的聚（邻苯二胺）可用于光热治疗。同时，肿瘤中过表达的 HO 在 Fenton 反应中，被 Fe/Fe 氧化还原对进一步催化和分解为羟基自由基（OH）。有趣的是，光热治疗引起的温度升高可以加速 OH 的产生。此外，在使用抗 PD-L1 检查点阻断的情况下，肿瘤相关抗原诱导了强烈的抗肿瘤免疫反应，并有效地抑制了肿瘤转移。这种基于 COF 的多功能纳米平台为原发性肿瘤和肿瘤转移提供了一种有效的治疗策略。
