Yang Tianyu, Deng Zhoubin, Wang Ke-Hu, Li Pengfei, Huang Danfeng, Su Yingpeng, Hu Yulai
College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
J Org Chem. 2020 Oct 2;85(19):12304-12314. doi: 10.1021/acs.joc.0c01568. Epub 2020 Sep 14.
A highly efficient strategy for the construction of CF-substituted 1,6-dihydropyridazines has been developed by cascade oxidation/cyclization of trifluoromethylated -acylhydrazines. The produced 1,6-dihydropyridazines could be easily transformed to 3-trifluoromethyl pyridazine derivatives. Some of the 1,6-dihydropyridazines exhibited aggregation-induced emission (AIE). DFT calculations were conducted to explain the mechanism.
通过三氟甲基化酰肼的级联氧化/环化反应，开发了一种构建CF取代的1,6-二氢哒嗪的高效策略。所制备的1,6-二氢哒嗪可轻松转化为3-三氟甲基哒嗪衍生物。部分1,6-二氢哒嗪表现出聚集诱导发光（AIE）特性。进行了密度泛函理论（DFT）计算以解释其机理。
