Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
J Control Release. 2020 Dec 10;328:407-424. doi: 10.1016/j.jconrel.2020.08.054. Epub 2020 Sep 1.
Bilirubin is a yellow-colored metabolite of heme degradation (a bile pigment), once believed to be toxic, but recently recognized as a powerful endogenous antioxidant of physiologic importance. During the past two decades, several studies have demonstrated the potential of bilirubin in theranostic applications. Here this paper summarizes the current state of the field, providing a detailed review of the published literature on the theranostic applications of bilirubin-conjugated nanoparticles and the basis and mechanisms underlying their efficacy. This review covers the analytical description of the construction of the nanoparticulate bilirubin system, primary mechanisms of therapeutic action, drug delivery, and imaging potential. It also lays out the possible translational future of bilirubin-conjugated nanoparticles in therapy and diagnosis.
胆红素是血红素降解（胆汁色素）的黄色代谢产物，曾被认为有毒，但最近被认为是具有生理重要性的强大内源性抗氧化剂。在过去的二十年中，多项研究表明胆红素在治疗诊断应用方面具有潜力。本文总结了该领域的现状，详细回顾了关于胆红素结合纳米粒子的治疗诊断应用的已发表文献，以及其疗效的基础和机制。本综述涵盖了对纳米粒子胆红素系统构建的分析描述、主要治疗作用机制、药物输送和成像潜力。它还阐述了胆红素结合纳米粒子在治疗和诊断中的可能转化未来。
