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运动训练可逆转经活检证实的非酒精性脂肪性肝炎患者的肠道菌群失调：概念验证研究。

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study.

机构信息

Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.

Division of Gastroenterology and Hepatology, Department of Medicine, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania.

出版信息

Clin Gastroenterol Hepatol. 2021 Aug;19(8):1723-1725. doi: 10.1016/j.cgh.2020.08.063. Epub 2020 Aug 31.

DOI:10.1016/j.cgh.2020.08.063
PMID:32882426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9067391/
Abstract

Nonalcoholic fatty liver disease is the leading cause of liver disease worldwide and can progress to nonalcoholic steatohepatitis (NASH) through physical inactivity and gut dysbiosis. Exercise training reverses gut dysbiosis in non-NASH persons with obesity and in NASH animal models. Consequently, we conducted a proof-of-concept study investigating the effect of exercise training on gut dysbiosis in NASH patients.

摘要

非酒精性脂肪性肝病是全球范围内导致肝脏疾病的主要原因，通过身体活动不足和肠道菌群失调，可进展为非酒精性脂肪性肝炎（NASH）。运动训练可逆转肥胖非 NASH 人群和 NASH 动物模型中的肠道菌群失调。因此，我们进行了一项概念验证研究，调查运动训练对 NASH 患者肠道菌群失调的影响。

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