多水平睡眠手术后阻塞性睡眠呼吸暂停患者的靶向代谢组学分析
Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery.
作者信息
Alterki Abdulmohsen, Joseph Shibu, Thanaraj Thangavel Alphonse, Al-Khairi Irina, Cherian Preethi, Channanath Arshad, Sriraman Devarajan, Ebrahim Mahmoud A K, Ibrahim Alaaeldin, Tiss Ali, Al-Mulla Fahd, Rahman Anas M Abdel, Abubaker Jehad, Abu-Farha Mohamed
机构信息
Department of Otolaryngology Head & Neck Surgery, Zain and Al Sabah Hospitals and Dasman Diabetes Institute, Dasman 15462, Kuwait.
Special Service Facility Department, Dasman Diabetes Institute, Dasman 15462, Kuwait.
出版信息
Metabolites. 2020 Sep 1;10(9):358. doi: 10.3390/metabo10090358.
BACKGROUND
Obstructive sleep apnea (OSA) is caused by partial or complete obstruction of the upper airways. Corrective surgeries aim at removing obstructions in the nasopharynx, oropharynx, and hypopharynx. OSA is associated with an increased risk of various metabolic diseases. Our objective was to evaluate the effect of surgery on the plasma metabolome.
METHODS
This study included 39 OSA patients who underwent Multilevel Sleep Surgery (MLS). Clinical and anthropometric measures were taken at baseline and five months after surgery.
RESULTS
The mean Apnea-Hypopnea Index (AHI) significantly dropped from 22.0 ± 18.5 events/hour to 8.97 ± 9.57 events/hour (-Value < 0.001). Epworth's sleepiness Score (ESS) dropped from 12.8 ± 6.23 to 2.95 ± 2.40 (-Value < 0.001), indicating the success of the surgery in treating OSA. Plasma levels of metabolites, phosphocholines (PC) PC.41.5, PC.42.3, ceremide (Cer) Cer.44.0, and triglyceride (TG) TG.53.6, TG.55.6 and TG.56.8 were decreased (-Value < 0.05), whereas lysophosphatidylcholines (LPC) 20.0 and PC.39.3 were increased (-Value < 0.05) after surgery.
CONCLUSION
This study highlights the success of MLS in treating OSA. Treatment of OSA resulted in an improvement of the metabolic status that was characterized by decreased TG, PCs, and Cer metabolites after surgery, indicating that the success of the surgery positively impacted the metabolic status of these patients.
背景
阻塞性睡眠呼吸暂停（OSA）是由上呼吸道部分或完全阻塞引起的。矫正手术旨在清除鼻咽、口咽和下咽的阻塞物。OSA与各种代谢性疾病风险增加有关。我们的目的是评估手术对血浆代谢组的影响。
方法
本研究纳入了39例行多级睡眠手术（MLS）的OSA患者。在基线和术后五个月进行临床和人体测量。
结果
平均呼吸暂停低通气指数（AHI）从22.0±18.5次/小时显著降至8.97±9.57次/小时（P值<0.001）。爱泼沃斯嗜睡量表（ESS）从12.8±6.23降至2.95±2.40（P值<0.001），表明手术治疗OSA成功。术后血浆中代谢物磷酸胆碱（PC）PC.41.5、PC.42.3、神经酰胺（Cer）Cer.44.0以及甘油三酯（TG）TG.53.6、TG.55.6和TG.56.8水平降低（P值<0.05），而溶血磷脂酰胆碱（LPC）20.0和PC.（此处PC后面数字不完整）39.3升高（P值<0.05）。
结论
本研究突出了多级睡眠手术治疗OSA的成功。OSA的治疗导致代谢状态改善，其特征为术后甘油三酯、磷酸胆碱和神经酰胺代谢物水平降低，表明手术成功对这些患者的代谢状态产生了积极影响。
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