Department of Otolaryngology Head & Neck Surgery, Zain and Al Sabah Hospitals and Dasman Diabetes Institute, 15462, Kuwait.
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, 15462, Kuwait.
Dis Markers. 2021 Oct 4;2021:1219593. doi: 10.1155/2021/1219593. eCollection 2021.
IGFBP4 is the smallest member of the insulin-like growth factor binding protein family (IGFBP). It is a hepatic protein that plays a role in modulating the activity and bioavailability of IGF-I. The expression of IGFBP4 was found to increase under conditions of hypoxia. Obstructive sleep apnea (OSA) is a common disorder, characterized by cyclic episodes of intermittent hypoxia and fragmented sleep. Our aim was to quantify levels of circulating IGFBP1, IGFBP2, IGFBP3, IGFBP4, and IGFBP7 in fasting plasma samples of 69 Kuwaiti participants and explore its correlation with indices of OSA. The quantification was performed using multiplexing assay. The study involved 28 controls and 41 patients with OSA. Levels of circulating IGFBP4 were significantly higher in people with OSA (289.74 ± 23.30 ng/ml) compared to the control group (217.60 ± 21.74 ng/ml, = 0.028). The increase in IGFBP4 correlated significantly and positively with AHI ( = .574, = .01) and AI ( = .794, = .001) in people with moderate and severe OSA. There was a significant decline in circulating IGFBP4 after 3 months of surgery (225.89 ± 18.16 ng/ml, = 0.012). This was accompanied by a prominent improvement in OSA (AHI 8.97 ± 2.37 events/h, = 0.001). In this study, our data showed a significant increase in circulating IGFBP4 in people with OSA. We also report a significant positive correlation between IGFBP4 and indices of OSA at baseline, which suggests IGFBP4 as a potential diagnostic biomarker for OSA. There was a significant improvement in OSA after 3 months of surgical intervention, which concurred with a significant decline in IGFBP4 levels. Altogether, the detected change suggests a potential link between IGFBP4 and OSA or an OSA-related factor, whereby OSA might play a role in triggering the induction of IGFBP4 expression.
IGFBP4 是胰岛素样生长因子结合蛋白家族（IGFBP）中最小的成员。它是一种肝脏蛋白，在调节 IGF-I 的活性和生物利用度方面发挥作用。研究发现，IGFBP4 的表达在缺氧条件下增加。阻塞性睡眠呼吸暂停（OSA）是一种常见的疾病，其特征是间歇性缺氧和睡眠片段化的周期性发作。我们的目的是在 69 名科威特参与者的空腹血浆样本中定量检测循环 IGFBP1、IGFBP2、IGFBP3、IGFBP4 和 IGFBP7 的水平，并探讨其与 OSA 指标的相关性。使用多重分析检测进行定量。该研究包括 28 名对照组和 41 名 OSA 患者。OSA 患者的循环 IGFBP4 水平明显高于对照组（289.74±23.30ng/ml 比 217.60±21.74ng/ml， = 0.028）。IGFBP4 的增加与中重度 OSA 患者的 AHI（ =.574， =.01）和 AI（ =.794， =.001）呈显著正相关。OSA 手术后 3 个月循环 IGFBP4 显著下降（225.89±18.16ng/ml， = 0.012）。同时，OSA 明显改善（AHI 8.97±2.37 次/小时， = 0.001）。在这项研究中，我们的数据显示 OSA 患者的循环 IGFBP4 显著增加。我们还报告了 IGFBP4 与 OSA 基线指标之间的显著正相关，这表明 IGFBP4 是 OSA 的潜在诊断生物标志物。手术后 3 个月 OSA 显著改善，同时 IGFBP4 水平显著下降。总的来说，检测到的变化表明 IGFBP4 与 OSA 或与 OSA 相关的因素之间可能存在关联，OSA 可能在触发 IGFBP4 表达诱导中发挥作用。
