Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA.
Lupus. 2020 Oct;29(12):1601-1615. doi: 10.1177/0961203320954520. Epub 2020 Sep 3.
Obstetric antiphospholipid syndrome (APS) remains a clinical challenge for practitioners, with several controversial points that have not been answered so far. This Obstetric APS Task Force met on the 16th International Congress on Antiphospholipid Antibodies in Manchester, England, to discuss about treatment, diagnostic and clinical aspects of the disease. This report will address evidence-based medicine related to obstetric APS, including limitations on our current management, the relationship between antibodies against domain 1 of β2GPI and obstetric morbidity, hydroxychloroquine use in patients with obstetric APS and factors associated with thrombosis after obstetric APS. Finally, future directions for better understanding this complex condition are also reported by the Task Force coordinators.
产科抗磷脂综合征（APS）仍然是临床医生面临的挑战，目前仍有一些有争议的问题尚未得到解答。该产科 APS 工作组于 2019 年在英国曼彻斯特举行的第 16 届国际抗磷脂抗体大会上举行会议，讨论了该疾病的治疗、诊断和临床方面。本报告将涉及与产科 APS 相关的循证医学，包括我们目前管理的局限性、针对β2GPI 结构域 1 的抗体与产科发病率之间的关系、羟氯喹在产科 APS 患者中的应用以及产科 APS 后血栓形成的相关因素。最后，工作组协调员还报告了更好地理解这种复杂情况的未来方向。
