Nocella Cristina, Bartimoccia Simona, Cammisotto Vittoria, D'Amico Alessandra, Pastori Daniele, Frati Giacomo, Sciarretta Sebastiano, Rosa Paolo, Felici Chiara, Riggio Oliviero, Calogero Antonella, Carnevale Roberto
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.
Antioxidants (Basel). 2021 Nov 9;10(11):1790. doi: 10.3390/antiox10111790.
Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients.
动脉粥样硬化血栓形成是抗磷脂综合征（APS）患者临床病史中常见的并发症。动脉粥样硬化血栓形成和APS均以氧化应激增加为特征。氧化修饰与抗磷脂抗体的形成有关，而抗磷脂抗体反过来可能通过增加活性氧（ROS）的产生或通过与促氧化剂/抗氧化酶的直接相互作用而加剧氧化失衡。由于这些过程，APS患者存在氧化失衡，这可能导致动脉粥样硬化进程的进展以及缺血性血栓并发症的发生。本综述的目的是描述APS患者中ROS形成的相关机制及其在动脉粥样硬化血栓形成过程中的作用。我们还概述了减轻氧化应激以及预防这些患者动脉粥样硬化血栓形成并发症的潜在治疗方法。
