Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Eur Urol Oncol. 2021 Aug;4(4):558-569. doi: 10.1016/j.euo.2020.08.003. Epub 2020 Aug 31.
Whole-mount histopathology, that is, large format histology or whole-mount sectioning, refers to the histopathological examination of tissue sections from specimens processed with large tissue cassette. In some institutions, it is applied routinely to specimens with genitourinary cancers.
To give an overview of the application of the large format histology to the morphological examination of the radical prostatectomy (RP) specimens.
A comprehensive PubMed search was performed up to May 2020, using the keywords "prostate carcinoma," "radical prostatectomy specimens," "whole-mount histopathology," "whole mount sectioning," "large format histology," "macrosectioning," "diagnostic criteria," and "prognosis." The search, supplemented with a hand search, was restricted to articles published in the English language. No limitations were placed on the publication year. References in relevant articles were also reviewed.
Even though the whole-mount sections of RPs appear not to be superior to regular sections in detecting adverse pathological features, their use has the advantage of displaying the architecture of the prostate gland and identifying and locating tumor nodule(s) more clearly, with particular reference to the index tumor. Further, it is easier to compare the pathological features with clinical findings derived, for instance, from digital rectal examination, transrectal ultrasound, multiparametric magnetic resonance imaging, surgical operation, and prostate biopsies.
Urologists, radiologists, and oncologists are updated about the step forward made by pathologists when diagnostic and prognostic information is derived from an approach that closely resembles that used by the clinicians when dealing with imaging findings.
Adoption of the whole-mount histopathology adds clinical value in correlation with clinical/imaging findings of radical prostatectomy specimens.
全器官组织病理学，即大格式组织学或全器官切片，是指对使用大型组织盒处理的标本进行组织切片的组织病理学检查。在一些机构，它被常规应用于泌尿生殖系统癌症的标本。
概述大格式组织学在根治性前列腺切除术（RP）标本形态学检查中的应用。
截至 2020 年 5 月，我们通过使用关键词“前列腺癌”、“根治性前列腺切除术标本”、“全器官组织病理学”、“全器官切片”、“大格式组织学”、“大体切片”、“诊断标准”和“预后”进行了全面的 PubMed 搜索。该搜索通过手工搜索进行了补充，仅限于以英语发表的文章。未对出版年份进行限制。还回顾了相关文章中的参考文献。
尽管 RP 的全器官切片在检测不良病理特征方面似乎并不优于常规切片，但它们的使用具有显示前列腺结构以及更清晰地识别和定位肿瘤结节的优势，特别是对于指数肿瘤。此外，与来自数字直肠检查、经直肠超声、多参数磁共振成像、手术和前列腺活检等的临床发现相比，更容易比较病理特征。
泌尿科医生、放射科医生和肿瘤学家了解了病理学家在从与临床医生处理影像学发现时非常相似的方法中获取诊断和预后信息时所取得的进展。
全器官组织病理学的应用在与根治性前列腺切除术标本的临床/影像学发现相关联时增加了临床价值。
