Yamaga Kensaku, Kuwamoto Satoshi, Mukunoki Daichi, Osaki Mari, Nagashima Hideki
Division of Orthopedic Surgery, Department of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan.
Department of Pathology, Tottori University Hospital, Yonago 683-8504, Japan.
Yonago Acta Med. 2020 Aug 20;63(3):228-233. doi: 10.33160/yam.2020.08.013. eCollection 2020 Aug.
We report a case of GCTB in an 84-year-old Japanese man who had a tumor in his left iliac bone and was treated safely with denosumab. The patient noticed a painful mass, with gradual enlargement, in his left low back next to the iliac region. Magnetic resonance imaging revealed that the tumor measured 94 × 66 × 90 mm and was located in the left iliac bone. Histologically, the tumor was composed of proliferative oval-shaped mononuclear cells, admixed with large number of osteoclast-like giant cells. Immunohistochemically, a strong positivity for histone 3.3 G34W mutant protein was observed in the nuclei of the mononuclear cells, confirming the diagnosis of GCTB. Because it was considered as unresectable tumor, the patient was treated with denosumab without any side effects.
我们报告了一例84岁日本男性的骨巨细胞瘤（GCTB）病例，该患者左髂骨有肿瘤，接受地诺单抗治疗且过程安全。患者注意到左下腹髂骨区域旁有一个逐渐增大的疼痛性肿块。磁共振成像显示肿瘤大小为94×66×90毫米，位于左髂骨。组织学上，肿瘤由增殖的椭圆形单核细胞组成，并混有大量破骨细胞样巨细胞。免疫组织化学检查显示，单核细胞核中组蛋白3.3 G34W突变蛋白呈强阳性，确诊为骨巨细胞瘤。由于该肿瘤被认为无法切除，患者接受了地诺单抗治疗，且未出现任何副作用。
