Niu Xiaohui, Xu Hairong, Inwards Carrie Y, Li Yuan, Ding Yi, Letson G Douglas, Bui Marilyn M
From the Departments of Orthopedic Oncology Surgery (Drs Niu, Xu, and Li) and Pathology (Dr Ding), Beijing Ji Shui Tan Hospital, Peking University, Beijing, China; the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Dr Inwards); the Department of Sarcoma (Drs Leston and Bui) and Anatomic Pathology Service (Dr Bui), H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Arch Pathol Lab Med. 2015 Sep;139(9):1149-55. doi: 10.5858/arpa.2014-0432-OA. Epub 2015 May 15.
Although primary bone tumors are extremely rare, the literature suggests that there are variations in the epidemiologic characteristics in different populations. The most frequently cited epidemiologic characteristics of primary bone tumors are derived from a large US series (Mayo Clinic), with no comparable study thus far performed in China.
To identify any potential epidemiologic differences between Chinese patients and a US series of patients.
We performed a comparison study between 9200 patients treated at Beijing Ji Shui Tan Hospital (JST) and 10 165 patients treated at Mayo Clinic (MC), Rochester Minnesota. Detailed epidemiologic features were analyzed.
We found that giant cell tumor and osteosarcoma have significantly higher incidences in the JST than the MC patients (P < .001). However, JST patients had a significantly lower incidence of Ewing sarcoma, chordoma, fibrosarcoma, myeloma, and malignant lymphoma (P < .001). For most benign and malignant bone tumors, the Chinese cohort had a more distinct male predominance than the US cohort. Malignant bone tumors had a monomodal age distribution in the JST patient group, with a bimodal age distribution in the MC cohort. Also, there were was a predilection for tumors of the femur and tibia among the JST patients (P < .001).
Our data confirm that epidemiologic variations of primary bone tumors exist in different populations. Factors that may contribute to these observed differences are proposed and discussed.
尽管原发性骨肿瘤极为罕见，但文献表明不同人群的流行病学特征存在差异。原发性骨肿瘤最常被引用的流行病学特征来自美国的一个大型系列研究（梅奥诊所），迄今为止中国尚未进行类似研究。
确定中国患者与美国患者系列之间是否存在潜在的流行病学差异。
我们对北京积水潭医院（JST）治疗的9200例患者和明尼苏达州罗切斯特市梅奥诊所（MC）治疗的10165例患者进行了比较研究。分析了详细的流行病学特征。
我们发现，JST患者的骨巨细胞瘤和骨肉瘤发病率显著高于MC患者（P <.001）。然而，JST患者的尤因肉瘤、脊索瘤、纤维肉瘤、骨髓瘤和恶性淋巴瘤发病率显著较低（P <.001）。对于大多数良性和恶性骨肿瘤，中国队列比美国队列更明显地以男性为主。恶性骨肿瘤在JST患者组中呈单峰年龄分布，在MC队列中呈双峰年龄分布。此外，JST患者中股骨和胫骨肿瘤的发生率较高（P <.001）。
我们的数据证实不同人群中存在原发性骨肿瘤的流行病学差异。提出并讨论了可能导致这些观察到的差异的因素。
