Oneda Ester, Zorzi Fausto, Gorio Antonio, Quaglia Federico, Abeni Chiara, Rota Luigina, Zaniboni Alberto
Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy.
Department of Pathology, Fondazione Poliambulanza, Brescia, Italy.
Case Rep Oncol. 2020 Jul 10;13(2):822-828. doi: 10.1159/000507978. eCollection 2020 May-Aug.
Small cell tumors arise from the neuroendocrine cell system and they are most frequently found in the lung (SCLC). Small cell tumor could occasionally arise in other body sites, such as the cervix, prostate, gastrointestinal tract, and very rarely from other sites. Metastatic SCLC patients present with metastatic disease in 80% of cases, and the metastases typically are reported in brain, liver, lung, and bone; they rarely could be found in the ovary. Differently, primitive small cell carcinoma of the ovary of pulmonary type is a rare and highly aggressive tumor arising from the ovarian cells; no suitable treatment strategy has been established yet. In this paper, we talk about a 72-year-old woman who presented with abdominal bleeding and a large mass in her pelvic region. A primary ovarian carcinoma was suspected, and she underwent hysterectomy with laparoscopic surgery and bilateral oophorectomy, lymph node resection, omentectomy, complementary appendix and sigmoid resection. The postoperative pathologic diagnosis was a differential diagnosis between small cell ovarian carcinoma of the pulmonary type and metastasis of SCLC.
小细胞肿瘤起源于神经内分泌细胞系统,最常见于肺部(小细胞肺癌)。小细胞肿瘤偶尔也可发生于身体其他部位,如子宫颈、前列腺、胃肠道,极少发生于其他部位。80%的小细胞肺癌转移患者存在转移性疾病,转移部位通常见于脑、肝、肺和骨;极少见于卵巢。不同的是,肺型原发性卵巢小细胞癌是一种罕见且侵袭性很强的肿瘤,起源于卵巢细胞;目前尚未确立合适的治疗策略。本文讲述了一名72岁女性,她出现腹部出血及盆腔巨大肿块。怀疑为原发性卵巢癌,她接受了腹腔镜下子宫切除术、双侧卵巢切除术、淋巴结切除术、大网膜切除术、阑尾及乙状结肠切除术。术后病理诊断为肺型卵巢小细胞癌与小细胞肺癌转移的鉴别诊断。