Acosta Rojas Angel, Collazo-Lorduy Ana, Remon Jordi, Hernando Requejo Ovidio, Jiménez-Munarriz Beatriz, Rubio Rodríguez María Carmen, De Castro Javier
Department of Radiation Oncology, Hospital Universitario Madrid Sanchinarro-CIOCC, Madrid, Spain.
Department of Medical Oncology, Hospital Universitario Madrid Sanchinarro-CIOCC, Madrid, Spain.
Case Rep Oncol. 2020 Jul 29;13(2):892-895. doi: 10.1159/000508360. eCollection 2020 May-Aug.
The incidence of lung cancer during pregnancy is rising due to the high rate of smokers in young women and the late mean age of pregnancy; in addition, considering that the patients are young women with a higher incidence of molecular alterations, molecular testing in lung adenocarcinoma should always be performed, even in pregnancy. Here, we report the case of a lung adenocarcinoma diagnosed during pregnancy with a long survival who benefitted from brain radiotherapy, conventional chemotherapy, and ALK TKI-targeted treatment. It reveals the safety of whole brain radiotherapy during pregnancy and consideration of other brain radiation techniques even in palliative cases, which should be personalized and managed by a multidisciplinary team. However, upfront management of brain metastasis in ALK-positive patients remains unresolved.
由于年轻女性吸烟率高以及平均怀孕年龄较晚，孕期肺癌的发病率正在上升；此外，鉴于患者为年轻女性且分子改变发生率较高，即使在孕期，肺腺癌的分子检测也应始终进行。在此，我们报告一例孕期诊断为肺腺癌且长期存活的病例，该患者受益于脑放疗、传统化疗和ALK酪氨酸激酶抑制剂靶向治疗。它揭示了孕期全脑放疗的安全性，以及即使在姑息治疗病例中对其他脑部放疗技术的考虑，这应由多学科团队进行个性化管理。然而，ALK阳性患者脑转移的前期管理仍未解决。
