Wu Ya, Yang Jun, Liu Xiaojing, Zhang Ying, Lei Ailing, Yi Ruokun, Tan Fang, Zhao Xin
Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China.
Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China.
Food Sci Nutr. 2020 Jul 8;8(8):4512-4522. doi: 10.1002/fsn3.1758. eCollection 2020 Aug.
Small-leaved Kuding tea (SLKDT; ) is a traditional Chinese tea. We systematically investigated the effect of SLKDT extract on obesity. SLKDT-controlled weight gain in mice fed a high-fat diet. Tissue specimen results showed that the SLKDT extract alleviated liver damage and fat accumulation. Meanwhile, SLKDT extract improved dyslipidemia by decreasing total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels and increasing high-density lipoprotein cholesterol levels. Furthermore, SLKDT extract reduced alanine aminotransferase, alkaline phosphatase, and aspartate transaminase levels in the serum and liver tissues; decreased inflammatory cytokines, including interleukin (IL)-1β, tumor necrosis factor-α, interferon-γ, and IL-6; and increased the anti-inflammatory cytokines, IL-4 and IL-10. The quantitative PCR results showed that SLKDT extract upregulated the mRNA expressions of peroxisome proliferator-activated receptor (PPAR)-α, lipoprotein lipase, carnitine palmitoyltransferase 1, and cholesterol 7 alpha hydroxylase and downregulated PPAR-γ and CCAAT/enhancer-binding protein-alpha mRNA expressions in the obese mouse livers to reduce adipocyte differentiation and fat accumulation, promote fat oxidation, and improve dyslipidemia, thereby inhibiting the immune response and alleviating liver injury. SLKDT shows a potential for preventing obesity and regulating obesity-related syndrome, so it is possible to be further developed as a novel treatment for fighting obesity.
小叶苦丁茶是一种传统的中国茶。我们系统地研究了小叶苦丁茶提取物对肥胖的影响。小叶苦丁茶可控制高脂饮食喂养小鼠的体重增加。组织标本结果显示，小叶苦丁茶提取物减轻了肝脏损伤和脂肪堆积。同时，小叶苦丁茶提取物通过降低总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平以及提高高密度脂蛋白胆固醇水平来改善血脂异常。此外，小叶苦丁茶提取物降低了血清和肝组织中的丙氨酸氨基转移酶、碱性磷酸酶和天冬氨酸氨基转移酶水平；减少了包括白细胞介素（IL）-1β、肿瘤坏死因子-α、干扰素-γ和IL-6在内的炎性细胞因子；并增加了抗炎细胞因子IL-4和IL-10。定量PCR结果表明，小叶苦丁茶提取物上调了肥胖小鼠肝脏中过氧化物酶体增殖物激活受体（PPAR）-α、脂蛋白脂肪酶、肉碱棕榈酰转移酶1和胆固醇7α羟化酶的mRNA表达，并下调了PPAR-γ和CCAAT/增强子结合蛋白-α的mRNA表达，以减少脂肪细胞分化和脂肪堆积，促进脂肪氧化，改善血脂异常，从而抑制免疫反应并减轻肝损伤。小叶苦丁茶显示出预防肥胖和调节肥胖相关综合征的潜力，因此有可能进一步开发成为一种对抗肥胖的新型治疗方法。
