Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT, Boston, Massachusetts 02115, USA.
Nature. 2017 Feb 8;542(7640):177-185. doi: 10.1038/nature21363.
Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.
适当调节和管理能量、底物多样性和数量，以及大分子的合成和分解过程，是细胞和生物生存的基础，对健康至关重要。免疫反应防御着细胞和多细胞组织，这是一个强大而关键的系统，通过它可以区分自我和非自我，识别和消除致病信号，保护组织内环境稳定。免疫反应和代谢之间存在着多层次的进化保守相互作用。适当维持这种微妙的平衡对健康至关重要，对肥胖、糖尿病和其他慢性非传染性疾病等许多病理状态都有重要影响。
