及叶中的苯乙醇苷和苯甲苷及其生物活性。

Phenylethanoid and Phenylmethanoid Glycosides from the Leaves of and Their Bioactivities.

机构信息

College of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, China.

Department of Laboratory Science of Public Health, West China School of Public Health, Sichuan University, Chengdu 610041, China.

出版信息

Molecules. 2022 Oct 31;27(21):7390. doi: 10.3390/molecules27217390.

DOI:10.3390/molecules27217390

PMID:36364215

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9657303/

Abstract

The phytochemical study on the leaves of , which have been used as Ku-Ding-Cha, led to the isolation and identification of three new phenylethanoid glycosides and three new phenylmethanoid glycosides, named ligurobustosides R (), R (), R (), S (), S (), and S (), and five reported phenylethanoid glycosides (-). In the bioactivity test, ()-osmanthuside B () displayed strong fatty acid synthase (FAS) inhibitory activity (IC: 4.55 ± 0.35 μM) as the positive control orlistat (IC: 4.46 ± 0.13 μM), while ligurobustosides R () and S (), ligupurpuroside B (), -ligupurpuroside B (), ligurobustoside N (), osmanthuside D (), and ()-osmanthuside B () showed stronger ABTS radical scavenging activity (IC: 2.68 ± 0.05~4.86 ± 0.06 μM) than the positive control L-(+)-ascorbic acid (IC: 10.06 ± 0.19 μM). This research provided a theoretical basis for the leaves of as a tea with function in treating obesity and diabetes.

摘要

对被用作苦丁茶的叶进行的植物化学研究，导致分离和鉴定出三种新的苯乙醇苷和三种新的苯甲烷苷，分别命名为 ligurobustosides R ()、R ()、R ()、S ()、S ()和 S ()，以及五种已报道的苯乙醇苷 (-)。在生物活性测试中，()-osmanthuside B () 显示出很强的脂肪酸合酶 (FAS) 抑制活性 (IC：4.55 ± 0.35 μM)，作为阳性对照奥利司他 (IC：4.46 ± 0.13 μM)，而 ligurobustosides R () 和 S ()、ligupurpuroside B ()、-ligupurpuroside B ()、ligurobustoside N ()、osmanthuside D () 和 ()-osmanthuside B () 表现出比阳性对照 L-(+)-抗坏血酸 (IC：2.68 ± 0.05~4.86 ± 0.06 μM) 更强的 ABTS 自由基清除活性。这项研究为叶作为一种具有治疗肥胖和糖尿病功能的茶提供了理论基础。