Sonuga Ayobola Abimbola, Sonuga Oyebola Oluwagbemiga
Department of Biochemistry, Lead City University, Ibadan, Nigeria.
Chemical Pathology Department, University College Hospital, Ibadan, Nigeria.
Biomed Hub. 2020 Jul 8;5(2):1177-1190. doi: 10.1159/000508207. eCollection 2020 May-Aug.
Gestational diabetes mellitus (GDM), a pregnancy complication, is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Vitamin D deficiency and insufficiency has recently been recognized as a contributing factor to the pathogenesis of GDM, and this link might be associated with hyperglycemia, insulin resistance, and inflammation, which are implicated in GDM.
This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM.
A case-control study in which 80 women attending the antenatal clinic of University College Hospital (UCH), Ibadan, Nigeria, were recruited; the women were grouped into controls (40 nondiabetic pregnant women) and cases (40 pregnant women with GDM). Blood samples were taken at the second trimester, and metabolites were quantified by standard laboratory methods. Student's test and Pearson correlation were used to compare variables and determine the relationship between variables, respectively.
Results showed significant ( < 0.05) low levels of serum vitamin D and zinc, and significant ( < 0.05) higher levels of FPG and serum insulin, ferritin, and CRP in the GDM group compared to the control group. In the GDM group, a positive weak relationship was observed between vitamin D and zinc ( = 0.18, < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP ( = -0.23, -0.21, -0.20, -0.46, respectively, < 0.05).
This study suggests that hypovitaminosis D might be associated with glucose intolerance, insulin insensitivity, and inflammation, which are factors implicated in the development and progression of GDM.
妊娠期糖尿病（GDM）是一种妊娠并发症，被定义为孕期出现或首次被识别的任何程度的葡萄糖不耐受。维生素D缺乏和不足最近被认为是GDM发病机制的一个促成因素，这种联系可能与高血糖、胰岛素抵抗和炎症有关，而这些因素与GDM有关。
本研究旨在调查GDM患者中维生素D、空腹血糖（FPG）、胰岛素、锌、铁蛋白和高敏C反应蛋白（CRP）之间的关系。
进行一项病例对照研究，招募了80名在尼日利亚伊巴丹大学学院医院（UCH）产前诊所就诊的女性；这些女性被分为对照组（40名非糖尿病孕妇）和病例组（40名GDM孕妇）。在孕中期采集血样，通过标准实验室方法对代谢物进行定量。分别使用学生t检验和Pearson相关性分析来比较变量并确定变量之间的关系。
结果显示，与对照组相比，GDM组血清维生素D和锌水平显著降低（P<0.05），FPG、血清胰岛素、铁蛋白和CRP水平显著升高（P<0.05）。在GDM组中，维生素D与锌之间存在弱正相关（r = 0.18，P<0.05），而维生素D与FPG、血清胰岛素、铁蛋白和CRP呈负相关（分别为r = -0.23、-0.21、-0.20、-0.46，P<0.05）。
本研究表明，维生素D缺乏可能与葡萄糖不耐受、胰岛素不敏感和炎症有关，而这些因素与GDM的发生和发展有关。
