Shams Behzad, Afshari Elnaz, Tajadini Mohammadhasan, Keikha Mojtaba, Qorbani Mostafa, Heshmat Ramin, Motlagh Mohammad Esmaeil, Kelishadi Roya
MD, Professor of Pediatrics, Pediatrics Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Medical student, Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Med J Islam Repub Iran. 2016 Oct 18;30:430. eCollection 2016.
Vitamin D (VitD) deficiency is a common worldwide problem. Some previous studies have shown that both Zinc (Zn) and VitD deficiency are prevalent in Iran. This study aimed to assess the relationship of serum Zn and vitamin D levels in a nationally representative sample of Iranian children and adolescents. This case-control study was conducted as a sub-study of a school-based surveillance program entitled "the CASPIAN-III Study". An equal number of individuals with and without hypovitaminosis D including 330 participants aged 10 to 18 years were selected. The correlation of serum 25 hydroxy vitamin D (25(OH) D), cardiometabolic factors and Zn concentrations was determined. Statistical analysis was done using one-way analysis of variance (ANOVA), Pearson's correlation, linear regression, and logistic regression. The mean age was not significantly different in participants with and without hypovitaminosis D (14.74±2.52 vs. 14.74±2.66 years, respectively, p>0.05). The mean 25(OH) D level was 6.34±1.47ng/ml in the group with hypovitaminosis D and 39.27±6.42ng/ml in controls. The mean Zn level was significantly lower in the hypovitaminosis D group than in controls (1.15±0.26 vs. 1.43±0.32μg/ml, respectively, p<0.001). The Pearson's analysis showed a positive and significant correlation between Zn and 25(OH) D serum levels (p<0.0001). Odds ratios analysis for VitD level between various quartiles of serum zinc concentration for all participants showed that the odds of higher levels of VitD increased by higher levels of Zn. We found significant associations between low serum concentrations of zinc and 25(OH) D. Food fortification or mineral supplementation should be considered in future health programs.
维生素D（VitD）缺乏是一个全球性的普遍问题。此前一些研究表明，伊朗同时存在锌（Zn）缺乏和维生素D缺乏的情况。本研究旨在评估伊朗儿童和青少年全国代表性样本中血清锌与维生素D水平之间的关系。 本病例对照研究是一项名为“里海-III研究”的学校监测项目的子研究。选取了数量相等的维生素D缺乏和非缺乏个体，包括330名10至18岁的参与者。测定了血清25羟维生素D（25(OH)D）、心脏代谢因素与锌浓度之间的相关性。使用单因素方差分析（ANOVA）、Pearson相关性分析、线性回归和逻辑回归进行统计分析。 维生素D缺乏和非缺乏参与者的平均年龄无显著差异（分别为14.74±2.52岁和14.74±2.66岁，p>0.05）。维生素D缺乏组的平均25(OH)D水平为6.34±1.47ng/ml，对照组为39.27±6.42ng/ml。维生素D缺乏组的平均锌水平显著低于对照组（分别为1.15±0.26μg/ml和1.43±0.32μg/ml，p<0.001）。Pearson分析显示锌与血清25(OH)D水平呈显著正相关（p<0.0001）。对所有参与者血清锌浓度不同四分位数之间的维生素D水平进行优势比分析表明，锌水平越高，维生素D水平升高的几率越大。 我们发现血清锌浓度低与25(OH)D之间存在显著关联。未来的健康项目应考虑食品强化或矿物质补充。
