通过与红细胞结合的双特异性抗体构建体清除β-淀粉样蛋白。
Clearance of amyloid-beta with bispecific antibody constructs bound to erythrocytes.
作者信息
Taylor Ronald P, Lindorfer Margaret A, Atkinson John P
机构信息
Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville Virginia USA.
Department of Medicine and Division of Rheumatology Washington University St. Louis Missouri USA.
出版信息
Alzheimers Dement (N Y). 2020 Aug 27;6(1):e12067. doi: 10.1002/trc2.12067. eCollection 2020.
We propose use of bispecific monoclonal antibody (mAb) complexes bound to erythrocytes to redress the lack of efficacy of anti-amyloid beta mAbs in Alzheimer's disease treatment. Our paradigm leverages erythrocyte complement receptor 1 to promote rapid and quantitative removal of amyloid beta from the circulation, and its subsequent removal from the brain as well.
我们建议使用与红细胞结合的双特异性单克隆抗体（mAb）复合物，以解决抗淀粉样β单克隆抗体在阿尔茨海默病治疗中缺乏疗效的问题。我们的模式利用红细胞补体受体1来促进从循环中快速定量清除淀粉样β，以及随后将其从大脑中清除。
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