Büttner Petra, Okun Jürgen G, Hauke Jana, Holzwirth Erik, Obradovic Danilo, Hindricks Gerhard, Thiele Holger, Kornej Jelena
Heart Center Leipzig at University Leipzig, Department of Cardiology, Leipzig 04289, Germany.
University Children's Hospital Heidelberg, Department of General Pediatrics, Division of Neuropediatrics and Metabolic Medicine, Heidelberg, Germany.
Int J Cardiol Heart Vasc. 2020 Jun 11;29:100554. doi: 10.1016/j.ijcha.2020.100554. eCollection 2020 Aug.
The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases. A potential involvement of increased TMAO in atrial fibrillation (AF) manifestation and progression is not clear. We measured TMAO in peripheral blood of 45 AF patients and 20 non-AF individuals (matched for age, sex, BMI, prevalence of hypertension and diabetes). TMAO levels in AF (median [IQR] 3.5 µM [2.51-4.53]) were comparable with those in non-AF individuals (3.62 µM [2.49-5.46]) (p = 0.629). There was no association between TMAO and AF progression phenotypes (p = 0.588). In 35 AF patients, TMAO was additionally measured 12-18 months after AF catheter ablation. TMAO levels at baseline and follow-up were correlated (r = 0.481, p = 0.003), and TMAO was increased independent from the success (restoration of sinus rhythm) of the ablation procedure. The data of this pilot study indicate that TMAO is not generally higher in AF and is not associated with AF progression phenotypes. The observed TMAO increase 12-18 months after AF catheter ablation needs further investigation in a larger cohort.
人类肠道微生物群及其代谢产物氧化三甲胺（TMAO）对人类饮食敏感，并参与构成糖尿病、肥胖症和心血管疾病基础的复杂病理机制。TMAO升高在心房颤动（AF）的发生和发展中是否有潜在作用尚不清楚。我们测量了45例AF患者和20例非AF个体（年龄、性别、BMI、高血压和糖尿病患病率相匹配）外周血中的TMAO。AF患者的TMAO水平（中位数[四分位间距]3.5µM[2.51 - 4.53]）与非AF个体（3.62µM[2.49 - 5.46]）相当（p = 0.629）。TMAO与AF进展表型之间无关联（p = 0.588）。在35例AF患者中，AF导管消融术后12 - 18个月额外测量了TMAO。基线和随访时的TMAO水平相关（r = 0.481，p = 0.003），且TMAO升高与消融手术的成功（恢复窦性心律）无关。这项初步研究的数据表明，AF患者的TMAO一般不会更高，且与AF进展表型无关。AF导管消融术后12 - 18个月观察到TMAO升高，这需要在更大的队列中进一步研究。
