Norström Fredrik, Namatovu Fredinah, Carlsson Annelie, Högberg Lotta, Ivarsson Anneli, Myléus Anna
Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Department of Historical, Philosophical and Religious Studies, Umeå University, Umeå, Sweden.
Acta Paediatr. 2021 Apr;110(4):1346-1352. doi: 10.1111/apa.15562. Epub 2020 Sep 20.
The aim of our study was to examine whether there is a difference in coeliac disease prevalence in regard to parents' education level and occupation, and whether this differs between screened and clinically diagnosed children at the age of 12 years.
The study, Exploring the Iceberg of Celiacs in Sweden (ETICS), was a school-based screening study of 12-year-old children that was undertaken during the school years 2005/2006 and 2009/2010. Data on parental education and occupation were reported from parents of the children. Specifically, by parents of 10 710 children without coeliac disease, 88 children diagnosed with coeliac disease through clinical care, and 231 who were diagnosed during the study.
There were no statistically significant associations between occupation and coeliac disease for either the clinically detected (prevalence ratio 1.16; confidence interval 0.76-1.76) or screening-detected coeliac disease cases (prevalence ratio 0.86; confidence interval 0.66-1.12) in comparison with children with no coeliac disease. Also, there were no statistically significant associations for parental education and coeliac disease diagnosis.
There was no apparent relationship between coeliac disease and socio-economic position. Using parents' socio-economic status as a tool to help identify children more likely to have coeliac disease is not recommended.
我们研究的目的是调查乳糜泻患病率在父母教育水平和职业方面是否存在差异，以及在12岁接受筛查和临床诊断的儿童之间是否存在差异。
“探索瑞典乳糜泻冰山”（ETICS）研究是一项针对12岁儿童的基于学校的筛查研究，于2005/2006学年和2009/2010学年进行。儿童家长报告了关于父母教育和职业的数据。具体而言，由10710名无乳糜泻儿童的家长、88名通过临床护理诊断为乳糜泻的儿童家长以及231名在研究期间被诊断出的儿童家长提供数据。
与无乳糜泻的儿童相比，无论是临床检测出的乳糜泻病例（患病率比值1.16；置信区间0.76 - 1.76）还是筛查检测出的乳糜泻病例（患病率比值0.86；置信区间0.66 - 1.12），职业与乳糜泻之间均无统计学上的显著关联。此外，父母教育程度与乳糜泻诊断之间也无统计学上的显著关联。
乳糜泻与社会经济地位之间没有明显关系。不建议将父母的社会经济地位作为帮助识别更可能患有乳糜泻儿童的工具。
