Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Cancer Sci. 2020 Oct;111(10):3873-3880. doi: 10.1111/cas.14623. Epub 2020 Sep 5.
In 1955, an outbreak of arsenic poisoning caused by the ingestion of arsenic-contaminated Morinaga Dry Milk occurred in western Japan. This study aimed to assess the mortality and cancer incidence risk among Japanese individuals who were poisoned during this time as infants. In total, 6223 survivors (mean age at enrollment, 27.5 y) who had ingested contaminated milk when they were aged ≤ 2 y participated in this study. Follow-up was conducted from 1982 to 2018 (mean follow-up duration, 30.3 y). Standardized mortality ratio (SMR) and standardized incidence ratio (SIR) were used to compare mortality and cancer incidence rates of subjects with the respective Japanese population rates, and 95% confidence intervals (95% CIs) of the SMR and SIR were also calculated. In total, 561 deaths and 524 new cancer cases were observed. A statistically significant increase in mortality rate was observed for all causes (SMR, 1.15; 1.01-1.19), nervous system disease (2.83, 1.62-4.19), respiratory disease (2.02, 1.37-2.62), genitourinary system disease (2.25, 1.10-3.73), and traffic accident (2.03, 1.14-3.04). In contrast, a significant decrease in cancer incidence rate was observed for all cancers (SIR, 0.96; 0.84-0.99), stomach cancer (0.77, 0.57-0.92), colon cancer (0.63, 0.41-0.85), rectum cancer (0.69, 0.43-0.95), and breast cancer (0.72, 0.52-0.89). Liver cancer showed a high mortality rate (SMR, 1.68; 1.06-2.31). In this study, after the long-term follow-up we revealed overall and cause-specific mortality and cancer incidence risk among survivors who ingested arsenic-contaminated dry milk as infants.
1955 年，日本西部发生了一起因摄入受砷污染的森永奶粉而导致的砷中毒事件。本研究旨在评估在此期间作为婴儿摄入受污染牛奶而中毒的日本个体的死亡率和癌症发病率风险。共有 6223 名幸存者（入组时的平均年龄为 27.5 岁）参与了这项研究，他们在≤2 岁时摄入了受污染的牛奶。从 1982 年到 2018 年进行了随访（平均随访时间为 30.3 年）。使用标准化死亡率比（SMR）和标准化发病比（SIR）来比较受试者的死亡率和癌症发病率与日本相应人群的比率，并计算了 SMR 和 SIR 的 95%置信区间（95%CI）。共观察到 561 例死亡和 524 例新发癌症病例。所有原因（SMR，1.15；1.01-1.19）、神经系统疾病（2.83，1.62-4.19）、呼吸道疾病（2.02，1.37-2.62）、泌尿系统疾病（2.25，1.10-3.73）和交通事故（2.03，1.14-3.04）的死亡率均呈统计学显著增加。相反，所有癌症（SIR，0.96；0.84-0.99）、胃癌（0.77，0.57-0.92）、结肠癌（0.63，0.41-0.85）、直肠癌（0.69，0.43-0.95）和乳腺癌（0.72，0.52-0.89）的癌症发病率呈显著下降。肝癌死亡率较高（SMR，1.68；1.06-2.31）。在这项长期随访研究中，我们揭示了作为婴儿摄入受污染干奶粉的幸存者的总体和特定原因死亡率和癌症发病率风险。
