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纳米技术应对 COVID-19。

Nanotechnology Responses to COVID-19.

机构信息

Materials Science Institute of Madrid, ICMM-CSIC, c/ Sor Juana Inés de la Cruz 3, Madrid, 28049, Spain.

CEMHTI, CNRS (UPR 3079), Université d'Orléans, Orléans, 45071, France.

出版信息

Adv Healthc Mater. 2020 Oct;9(19):e2000979. doi: 10.1002/adhm.202000979. Epub 2020 Sep 3.

DOI:10.1002/adhm.202000979
PMID:32885616
Abstract

Researchers, engineers, and medical doctors are made aware of the severity of the COVID-19 infection and act quickly against the coronavirus SARS-CoV-2 using a large variety of tools. In this review, a panoply of nanoscience and nanotechnology approaches show how these disciplines can help the medical, technical, and scientific communities to fight the pandemic, highlighting the development of nanomaterials for detection, sanitation, therapies, and vaccines. SARS-CoV-2, which can be regarded as a functional core-shell nanoparticle (NP), can interact with diverse materials in its vicinity and remains attached for variable times while preserving its bioactivity. These studies are critical for the appropriate use of controlled disinfection systems. Other nanotechnological approaches are also decisive for the development of improved novel testing and diagnosis kits of coronavirus that are urgently required. Therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. A brief overview on patented work is presented that emphasizes nanotechnology applied to coronaviruses. Finally, some comments are made on patents of the initial technological responses to COVID-19 that have already been put in practice.

摘要

研究人员、工程师和医生意识到 COVID-19 感染的严重性,并利用各种工具迅速对抗冠状病毒 SARS-CoV-2。在这篇综述中,一系列纳米科学和纳米技术方法表明,这些学科如何帮助医学、技术和科学界对抗这一流行病,强调了用于检测、卫生、治疗和疫苗的纳米材料的发展。SARS-CoV-2 可以被视为一种功能性核壳纳米颗粒 (NP),可以与附近的各种材料相互作用,并在保持其生物活性的同时附着在不同的时间。这些研究对于适当使用受控消毒系统至关重要。其他纳米技术方法对于开发急需的改进型新型冠状病毒检测和诊断试剂盒也至关重要。治疗也基于纳米技术策略,重点是抗病毒药物设计和新型纳米结构疫苗。简要概述了已申请专利的工作,强调了纳米技术在冠状病毒中的应用。最后,对已经付诸实践的 COVID-19 初始技术应对措施的专利进行了一些评论。

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