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转化生长因子-β1 诱导结缔组织生长因子表达并促进胃癌腹膜转移。

Transforming growth factor-β1 induces connective tissue growth factor expression and promotes peritoneal metastasis of gastric cancer.

机构信息

Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

Department of Cell Biology, China Medical University, Shenyang, Liaoning Province, China.

出版信息

Biosci Rep. 2020 Sep 30;40(9). doi: 10.1042/BSR20201501.

DOI:10.1042/BSR20201501
PMID:32885819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7502695/
Abstract

Transforming growth factor-β1 (TGF-β1) is involved in human cancer development and progression. Nonetheless, the role of TGF-β1 as regards peritoneal metastasis of gastric cancer has not been completely characterized. In the present study, we investigated the exact role of TGF-β1 on peritoneal metastasis of gastric cancer. The results indicated that human peritoneal mesothelial cells (HPMCs) exposed to TGF-β1 or serum-free conditional medium (SF-CM) of SGC7901 that produced a large amount of TGF-β1 became exfoliated, apoptosis and exhibited signs of injury, and the tumor-mesothelial cell adhesion significantly increased. Connective tissue growth factor (CTGF) expression was also increased when HPMCs were exposed to TGF-β1 or SF-CM of SGC7901. However, these effects were significantly decreased when HPMCs were exposed to SF-CM of SGC7901-TGFβS, a TGF-β1 knockdown stable cell line. Animal studies revealed that nude mice injected with SGC7901-TGFβS cells featured a smaller number of peritoneal seeding nodules and lower expression of CTGF in ascites than the control cell lines. These findings suggest that TGF-β1 promotes peritoneal metastasis of gastric cancer and induces CTGF expression. Therefore, blockage of TGF-β1 or TGF-β1 signaling pathway might prevent and treat peritoneal metastasis of gastric cancer.

摘要

转化生长因子-β1（TGF-β1）参与人类癌症的发生和发展。然而，TGF-β1 在胃癌腹膜转移中的作用尚未完全阐明。在本研究中，我们研究了 TGF-β1 对胃癌腹膜转移的确切作用。结果表明，人腹膜间皮细胞（HPMCs）暴露于 TGF-β1 或大量产生 TGF-β1 的 SGC7901 的无血清条件培养基（SF-CM）中会脱落、凋亡并出现损伤迹象，肿瘤-间皮细胞黏附明显增加。当 HPMCs 暴露于 TGF-β1 或 SGC7901 的 SF-CM 时，结缔组织生长因子（CTGF）的表达也增加。然而，当 HPMCs 暴露于 TGF-β1 敲低稳定细胞系 SGC7901-TGFβS 的 SF-CM 时，这些作用明显降低。动物研究表明，与对照细胞系相比，注射 SGC7901-TGFβS 细胞的裸鼠腹膜种植结节数量较少，腹水 CTGF 表达水平较低。这些发现表明 TGF-β1 促进胃癌腹膜转移并诱导 CTGF 表达。因此，阻断 TGF-β1 或 TGF-β1 信号通路可能预防和治疗胃癌腹膜转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/c960d3a50841/bsr-40-bsr20201501-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/3bad60f5d769/bsr-40-bsr20201501-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/42d80544120c/bsr-40-bsr20201501-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/daad93fe353b/bsr-40-bsr20201501-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/2b38918f63b0/bsr-40-bsr20201501-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/7c9fb47692c9/bsr-40-bsr20201501-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/a5c001c5c22e/bsr-40-bsr20201501-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/ae8a4af578a5/bsr-40-bsr20201501-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/c960d3a50841/bsr-40-bsr20201501-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/3bad60f5d769/bsr-40-bsr20201501-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/42d80544120c/bsr-40-bsr20201501-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/daad93fe353b/bsr-40-bsr20201501-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/2b38918f63b0/bsr-40-bsr20201501-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/7c9fb47692c9/bsr-40-bsr20201501-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/a5c001c5c22e/bsr-40-bsr20201501-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/ae8a4af578a5/bsr-40-bsr20201501-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f158/7502695/c960d3a50841/bsr-40-bsr20201501-g8.jpg

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