呼吸道合胞病毒相关性急性中耳炎在婴儿和儿童中的发病情况。

Respiratory Syncytial Virus-associated Acute Otitis Media in Infants and Children.

机构信息

Center for Observational and Real-World Evidence, Merck & Co, Inc, Kenilworth, New Jersey, USA.

Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.

出版信息

J Pediatric Infect Dis Soc. 2020 Nov 10;9(5):544-550. doi: 10.1093/jpids/piaa094.

DOI:10.1093/jpids/piaa094

PMID:32886769

Abstract

Despite recent declines in the incidence of acute otitis media (AOM), more than 5 million cases and 5-6 million primary AOM visits still occur in young children in the United States, resulting in $4.4 billion direct medical costs annually. Our aims in this review are to describe the role of respiratory syncytial virus (RSV) in the etiology of AOM, discuss the prospect of prevention of RSV-associated AOM through immunization, and suggest future research strategies to assess the impact of immunization on RSV-associated AOM.

摘要

尽管急性中耳炎 (AOM) 的发病率最近有所下降，但在美国，仍有超过 500 万例和 500 万至 600 万例的急性中耳炎初诊病例发生在幼儿中，每年导致直接医疗费用 44 亿美元。我们在本次综述中的目的是描述呼吸道合胞病毒 (RSV) 在 AOM 病因学中的作用，讨论通过免疫接种预防 RSV 相关 AOM 的前景，并提出评估免疫接种对 RSV 相关 AOM 影响的未来研究策略。