饮食草酸盐摄入量与肾脏结局。
Dietary Oxalate Intake and Kidney Outcomes.
机构信息
U.O.C. Nefrologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
出版信息
Nutrients. 2020 Sep 2;12(9):2673. doi: 10.3390/nu12092673.
Abstract
Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes.
摘要
草酸盐既是一种植物源性分子，也是一种终末毒性代谢产物，在人类中没有已知的生理功能。它主要通过肾脏的肾小球滤过和肾小管分泌来清除。无论病因如何，摄入的膳食草酸盐增加，都会导致不同的肾脏相关疾病和损伤，包括草酸钙肾结石、急性和慢性肾脏病。本文综述了膳食草酸盐摄入与肾脏结局之间关系的现有文献。
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