乙型肝炎病毒复制的生物标志物：概述与展望。
Biomarkers for hepatitis B virus replication: an overview and a look to the future.
机构信息
Department of Hepatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan, China.
Department of Nuclear Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University , Jinan, China.
出版信息
Expert Rev Gastroenterol Hepatol. 2020 Dec;14(12):1131-1139. doi: 10.1080/17474124.2020.1815530. Epub 2020 Sep 17.
INTRODUCTION
Hepatitis B virus (HBV) infection is a major public health issue but there are no powerful drugs to eradicate the virus. HBV markers including HBsAg, HBcrAg, HBV RNA, HBcAb, and HBV DNA are becoming promising biomarkers to reflect the natural phases of chronic HBV infection and predict the outcome of anti-HBV treatment.
AREAS COVERED
The authors summarized the biomarkers of HBV replication and presented the current advances of these biomarkers on predicting the outcome of anti-HBV treatment and identifying the progression of chronic HBV infection.
EXPERT OPINION
HBsAg, HBcrAg, HBV RNA, HBcAb, and HBV DNA are noninvasive and feasible biomarkers for monitoring the process of anti-HBV therapy and predicting the progress of HBV infection. However, there are still no strong biomarkers with high sensitivity and specificity for clinical application. Combination of two or more HBV biomarkers, new technique for measuring HBV cccDNA, and searching novel HBV biomarkers are essential for anti-HBV treatment in the future.
简介
乙型肝炎病毒（HBV）感染是一个主要的公共卫生问题，但目前尚无能够彻底清除病毒的有效药物。HBV 标志物（包括 HBsAg、HBcrAg、HBV RNA、HBcAb 和 HBV DNA）正成为反映慢性 HBV 感染自然阶段和预测抗 HBV 治疗效果的有前途的生物标志物。
涵盖领域
作者总结了 HBV 复制的生物标志物，并介绍了这些标志物在预测抗 HBV 治疗效果和识别慢性 HBV 感染进展方面的最新进展。
专家意见
HBsAg、HBcrAg、HBV RNA、HBcAb 和 HBV DNA 是监测抗 HBV 治疗过程和预测 HBV 感染进展的非侵入性和可行的生物标志物。然而，目前仍然没有具有高灵敏度和特异性的强生物标志物用于临床应用。未来，联合使用两种或多种 HBV 标志物、用于测量 HBV cccDNA 的新技术以及寻找新的 HBV 标志物对于抗 HBV 治疗至关重要。
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