Russell M L, Hanna W M
Department of Medicine, Women's College Hospital, University of Toronto, ON, Canada.
J Rheumatol. 1988 Mar;15(3):445-53.
Seventy-three muscle biopsies from patients with various rheumatic diseases were analyzed using immunofluorescence, light, and ultrastructural microscopy. Pathologic data were correlated with clinical variables of local muscle and systemic disease. Light and immunofluorescence findings were generally normal. Ultrastructure differed from normals, showing a spectrum of nonspecific changes. There were no disease specific pathologic features. Myofibrillar damage was the most common pathologic change, with atrophy or degeneration occurring in a majority of biopsies. Semiquantitative analysis showed a general correlation between the extent of pathologic change and muscle weakness.
对73例患有各种风湿性疾病患者的肌肉活检样本进行了免疫荧光、光学和超微结构显微镜分析。病理数据与局部肌肉和全身性疾病的临床变量相关。光学和免疫荧光检查结果通常正常。超微结构与正常情况不同，呈现出一系列非特异性变化。没有疾病特异性的病理特征。肌原纤维损伤是最常见的病理变化，大多数活检样本中出现萎缩或变性。半定量分析表明，病理变化程度与肌肉无力之间存在普遍相关性。
