Fassbender R, Annefeld M
Dtsch Med Wochenschr. 1986 Nov 21;111(47):1799-804. doi: 10.1055/s-2008-1068714.
Skeletal muscle from 21 patients with clinical confirmed polymyalgia rheumatica (PMR) were examined electronmicroscopically. The changes were classified according to 15 ultrastructure criteria. The focal changes have a regressive character and, while they are nonspecific, the systematic assessment of all criteria produced a characteristic pattern in which the ultrastructural picture of skeletal muscles provided a certain profile in cases of PMR. The functionally most important ultrastructural change concerns the mitochondria. Deposition and deformation of crystals result in mitochondrial changes which are structurally definable and are harmful to cell respiration. They are compensated by new formation and accumulation of mitochondria. Comparative analysis of regressive skeletal changes and of processes in the region of the media of the muscular arteries demonstrates analogous morphological changes which point to a common harmful and overlying systemic process in PMR and giant cell arteritis. Changes in the ultrastructure of the kind and degree described cannot be explained by inflammatory or noninflammatory arterial occlusions.
对21例临床确诊为风湿性多肌痛（PMR）患者的骨骼肌进行了电子显微镜检查。根据15项超微结构标准对这些变化进行分类。局灶性变化具有退行性特征，虽然它们是非特异性的，但对所有标准进行系统评估产生了一种特征性模式，其中骨骼肌的超微结构图像在PMR病例中呈现出一定的特征。功能上最重要的超微结构变化涉及线粒体。晶体的沉积和变形导致线粒体变化，这些变化在结构上是可定义的，并且对细胞呼吸有害。它们通过线粒体的新形成和积累得到补偿。对退行性骨骼变化和肌肉动脉中膜区域过程的比较分析表明，形态学变化相似，这表明PMR和巨细胞动脉炎存在共同的有害且普遍的全身过程。所述类型和程度的超微结构变化不能用炎症性或非炎症性动脉闭塞来解释。
