Centre for Microsystems Technology (CMST), Ghent University and Imec, Technologiepark 126, 9052, Ghent, Belgium.
Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Avda. Reyes Católicos 2, 28040, Madrid, Spain.
Sci Rep. 2020 Sep 4;10(1):14641. doi: 10.1038/s41598-020-71376-1.
This paper presents the simulated performance assessment of an artificial iris embedded on a scleral contact lens using real data from an aniridia patient. The artificial iris is based on guest-host liquid crystal cells (GH-LCD) in order to actively modify the transmittance of the lens and effective pupil size. Experimental validation of the GH-LCD spectrum and iris contrast (determined to be 1:2.1) enabled the development of optical models that include the effect of a small pupil on image quality and visual quality on an optical system with aniridia characteristics. Visual simulations at different light conditions (high/low photopic and mesopic) demonstrated the theoretical capacity of the customized artificial iris smart contact lens to expand the depth-of-focus and decrease the optical aberrations (in particular, the spherical aberration). The visual modelling suggests a maximum depth-of-focus value for a 2-mm pupil diameter for both eyes as follows: 3D (1,000 cd/m), 2D (10 cd/m) and 0.75D (1 cd/m). This work demonstrates the beneficial optical effects of an active artificial iris, based on visual simulations in response to different light levels, and enables further experimental investigation on patients to validate the dynamic light attenuation and visual performance of smart contact lenses with GH-LCD.
本文提出了一种基于客体-主体液晶单元（GH-LCD）的巩膜接触镜内置人工虹膜的模拟性能评估，该人工虹膜可主动调节镜片的透过率和有效瞳孔大小。利用来自无虹膜症患者的真实数据对 GH-LCD 光谱和虹膜对比度（确定为 1:2.1）进行实验验证，从而开发出了光学模型，这些模型考虑了小瞳孔对具有无虹膜症特征的光学系统的像质和视觉质量的影响。在不同光照条件（高/低明视觉和中间视觉）下进行的视觉模拟表明，具有定制人工虹膜的智能接触镜具有扩展景深和降低像差（特别是球差）的理论能力。视觉建模表明，对于 2mm 瞳孔直径的双眼，最大景深值如下：3D（1000 cd/m²）、2D（10 cd/m²）和 0.75D（1 cd/m²）。这项工作展示了基于对不同光照水平的视觉模拟的主动人工虹膜的有益光学效果，并为进一步在患者身上进行实验研究以验证具有 GH-LCD 的智能接触镜的动态光衰减和视觉性能奠定了基础。
