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本文引用的文献

1
Circulating MicroRNAs and Treatment Response in Childhood Asthma.循环 microRNAs 与儿童哮喘的治疗反应。
Am J Respir Crit Care Med. 2020 Jul 1;202(1):65-72. doi: 10.1164/rccm.201907-1454OC.
2
Remission of persistent childhood asthma: Early predictors of adult outcomes.儿童哮喘持续缓解：成人结局的早期预测指标。
J Allergy Clin Immunol. 2019 May;143(5):1752-1759.e6. doi: 10.1016/j.jaci.2018.09.038. Epub 2018 Nov 14.
3
Asthma remission: Predicting future airways responsiveness using an miRNA network.哮喘缓解：利用微小RNA网络预测未来气道反应性
J Allergy Clin Immunol. 2017 Aug;140(2):598-600.e8. doi: 10.1016/j.jaci.2017.01.023. Epub 2017 Feb 24.
4
MiR-221 promotes IgE-mediated activation of mast cells degranulation by PI3K/Akt/PLCγ/Ca(2+) pathway.微小RNA-221通过PI3K/Akt/PLCγ/Ca(2+)信号通路促进IgE介导的肥大细胞脱颗粒激活。
J Bioenerg Biomembr. 2016 Jun;48(3):293-9. doi: 10.1007/s10863-016-9659-7. Epub 2016 Apr 25.
5
Predicting asthma outcomes.预测哮喘结局。
J Allergy Clin Immunol. 2015 Oct;136(4):829-36; quiz 837. doi: 10.1016/j.jaci.2015.04.048.
6
Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects.空气毒物与表观遗传效应：臭氧改变人类痰液中的 microRNAs。
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1129-37. doi: 10.1152/ajplung.00348.2013. Epub 2014 Apr 25.
7
Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma.气道平滑肌过度增生受重症哮喘中 microRNA-221 的调控。
Am J Respir Cell Mol Biol. 2014 Jan;50(1):7-17. doi: 10.1165/rcmb.2013-0067OC.
8
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood.一项基于人群的儿童哮喘队列纵向研究，随访至成年期。
N Engl J Med. 2003 Oct 9;349(15):1414-22. doi: 10.1056/NEJMoa022363.
9
The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group.儿童哮喘管理项目（CAMP）：设计、基本原理及方法。儿童哮喘管理项目研究组
Control Clin Trials. 1999 Feb;20(1):91-120.

增强儿童哮喘缓解预测：将临床因素与 microRNAs 相结合。

Enhancing the prediction of childhood asthma remission: Integrating clinical factors with microRNAs.

机构信息

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass.

出版信息

J Allergy Clin Immunol. 2021 Mar;147(3):1093-1095.e1. doi: 10.1016/j.jaci.2020.08.019. Epub 2020 Sep 2.

DOI:10.1016/j.jaci.2020.08.019
PMID:32888944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8515417/
Abstract

The novel integration of baseline clinical and microRNA variables significantly improves the long-term individualized prediction of childhood asthma remission by early adulthood compared to using clinical variables alone.

摘要

基线临床和 microRNA 变量的新综合分析显著提高了对儿童期哮喘缓解至成年早期的长期个体化预测能力，优于单独使用临床变量。