色氨酸代谢的犬尿氨酸途径在体外循环婴儿心脏手术后的激活：一项前瞻性队列研究。
Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study.
机构信息
University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA.
University of Colorado Denver Department of Anesthesiology, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA.
出版信息
Metabolomics. 2020 Sep 5;16(9):93. doi: 10.1007/s11306-020-01714-x.
Abstract
BACKGROUND
Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed.
AIMS
To map changes in the KP induced by infant CPB.
METHODS
Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry.
RESULTS
Infant CPB results in marked increase in proximal, but not distal metabolites of the KP.
CONCLUSIONS
Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.
摘要
背景
血清犬尿氨酸酸与婴儿体外循环（CPB）后的不良预后相关，但 CPB 后犬尿氨酸途径（KP）的综合图谱尚未完成。
目的
绘制婴儿 CPB 诱导的 KP 变化图谱。
方法
通过液相色谱-串联质谱法比较术后 48 小时内血清 KP 代谢物的变化。
结果
婴儿 CPB 导致 KP 的近端代谢物而非远端代谢物明显增加。
结论
婴儿 CPB 导致循环 KP 代谢物的积累，这些代谢物具有重要的神经和免疫活性。因此，在这些高危婴儿中进一步探索 KP 是有必要的。
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