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泛转移性癌症的预后因素分析及基于预后的转移性癌症分类系统。

Pan-metastatic cancer analysis of prognostic factors and a prognosis-based metastatic cancer classification system.

机构信息

Department of Bone and Soft Tissue Tumours, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China.

Department of Orthopedics, Tianjin Hospital, Tianjin 300060, China.

出版信息

Aging (Albany NY). 2020 Aug 27;12(16):16046-16061. doi: 10.18632/aging.103467.

DOI:10.18632/aging.103467
PMID:32889800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7485706/
Abstract

We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at admission and overall survival were determined. A prognosis-based metastatic cancer classification was established based on the identified prognostic factors. The differences in prognosis among these categories were tested. The survival rate and prognostic factors were not consistent across cancers. Three metastatic cancer categories were generated, each with different prognoses. The prognostic differences among the categories were satisfactorily validated. Different metastatic cancer types had homogeneous and heterogeneous survival rates and prognostic factors. A prognosis-based classification system for synchronous distant metastasis cancer patients at admission was created. This classification system reflects the grade of malignancy in metastatic cancers and may guide the prediction of survival and individualized treatment. Moreover, it may have important implications for the management of synchronous metastatic cancers and aid clinicians in properly allocating medical resources to metastatic patients.

摘要

我们旨在对生存和预后因素进行泛转移性癌症分析，并建立一个基于预后的分类系统。我们从监测、流行病学和最终结果 (SEER) 数据库中选择了远处转移的患者。确定了入院时患者特征与总生存率之间的关系。根据确定的预后因素建立了基于预后的转移性癌症分类。测试了这些类别的预后差异。不同癌症的生存率和预后因素不一致。生成了三个转移性癌症类别，每个类别都有不同的预后。类别之间的预后差异得到了令人满意的验证。不同的转移性癌症类型具有同质和异质的生存率和预后因素。为入院时的同步远处转移癌症患者创建了基于预后的分类系统。该分类系统反映了转移性癌症的恶性程度，可能有助于预测生存和个体化治疗。此外，它可能对同步转移性癌症的管理具有重要意义，并帮助临床医生将医疗资源适当地分配给转移性患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40ac/7485706/bc83ac9fcd96/aging-12-103467-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40ac/7485706/bc83ac9fcd96/aging-12-103467-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40ac/7485706/a2c695d24ddc/aging-12-103467-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40ac/7485706/879dcfa4299e/aging-12-103467-g001b.jpg
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