Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam.
Aix Marseille University, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France.
Int J Infect Dis. 2020 Nov;100:104-111. doi: 10.1016/j.ijid.2020.08.075. Epub 2020 Sep 2.
To investigate symptoms of infections and their risk factors among French medical students undertaking an internship abroad.
Clinical follow up, and qPCR-based respiratory, gastrointestinal, and vaginal pathogen carriages were prospectively assessed pre-travel and post-travel, in a cohort of medical students departing from Marseille, France.
293 students were included. 63.5%, 35.8%, and 3.6% of students reported gastrointestinal, respiratory, and vaginal symptoms, respectively. The acquisition rate of Enteroaggregative Escherichia coli and Enteropathogenic E. coli was 40.9% and 18.6%, respectively. A significant increase was observed for rhinovirus and Streptococcus pneumoniae by comparing the prevalence of pathogens in pre-travel and post-travel samples. Gardnerella vaginalis and Atopobium vaginae acquisition rates were 12.9% and 13.9%, respectively. Being female, primarily traveling to Vietnam, and living in basic accommodation conditions were independent risk factors for reporting respiratory symptoms. Students reporting respiratory symptoms were three times more likely to acquire S. pneumoniae. Traveling primarily to north India and Senegal were independent risk factors for diarrhea.
This study makes it possible to identify the leading infectious diseases linked to travel in a group of French medical students undertaking an internship abroad and the risk factors on which to base targeting students for reinforced pre-travel advice.
调查在法留学生实习期间感染症状及其危险因素。
对马赛出发的留学生进行临床随访，以及基于 qPCR 的呼吸道、胃肠道和阴道病原体载量的前瞻性评估。
共纳入 293 名学生。分别有 63.5%、35.8%和 3.6%的学生报告有胃肠道、呼吸道和阴道症状。肠聚集性大肠埃希菌和肠致病性大肠埃希菌的检出率分别为 40.9%和 18.6%。通过比较旅行前后样本中病原体的流行率，发现鼻病毒和肺炎链球菌显著增加。阴道加德纳菌和阴道阿托波菌的检出率分别为 12.9%和 13.9%。女性、主要前往越南旅行以及居住在基本住宿条件是报告呼吸道症状的独立危险因素。报告呼吸道症状的学生感染肺炎链球菌的可能性增加了三倍。主要前往北印度和塞内加尔旅行是腹泻的独立危险因素。
本研究可识别与在法留学生实习相关的主要传染病及其危险因素，为有针对性地加强旅行前咨询提供依据。
