遗传性额颞叶痴呆和肌萎缩侧索硬化症的神经影像学。
Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.
机构信息
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Neurobiol Dis. 2020 Nov;145:105063. doi: 10.1016/j.nbd.2020.105063. Epub 2020 Sep 2.
Abstract
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong clinical, genetic and pathological overlap. This review focuses on the current understanding of structural, functional and molecular neuroimaging signatures of genetic FTD and ALS. We overview quantitative neuroimaging studies on the most common genes associated with FTD (MAPT, GRN), ALS (SOD1), and both (C9orf72), and summarize visual observations of images reported in the rarer genes (CHMP2B, TARDBP, FUS, OPTN, VCP, UBQLN2, SQSTM1, TREM2, CHCHD10, TBK1).
摘要
额颞叶痴呆（FTD）和肌萎缩侧索硬化症（ALS）在临床、遗传和病理方面有很强的重叠。这篇综述重点介绍了遗传 FTD 和 ALS 的结构、功能和分子神经影像学特征的现有认识。我们综述了与 FTD（MAPT、GRN）、ALS（SOD1）以及两者（C9orf72）相关的最常见基因的定量神经影像学研究，并总结了在较罕见基因（CHMP2B、TARDBP、FUS、OPTN、VCP、UBQLN2、SQSTM1、TREM2、CHCHD10、TBK1）中报告的图像的直观观察结果。
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