Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Division of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, 6410 Fannin Street, UT Professional Building, Suite 1100.05, Houston, 77030, TX, USA.
J Autism Dev Disord. 2021 Jun;51(6):1953-1965. doi: 10.1007/s10803-020-04677-z.
Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.
利用来自 266 对年龄和性别匹配的牙买加自闭症谱系障碍 (ASD) 儿童和典型发育 (TD) 对照 (2-8 岁) 的数据，我们研究了谷胱甘肽 S-转移酶 theta 1 (GSTT1) 是否改变了血锰浓度 (BMC) 与 ASD 之间的关联。在用 GSTT1 和 GSTP1 (谷胱甘肽 S-转移酶 pi 1) 之间的隐性遗传模型对社会经济地位和 GSTT1 和 GSTP1 之间的相互作用进行调整后，使用 GSTT1 的共显性或显性模型，GSTT1 和 BMC 之间的相互作用具有统计学意义 (P=0.02，P=0.01)。与对照组相比，GSTT1-DD 基因型的 ASD 病例的 BMC>12 vs. ≤8.3μg/L 的比值比分别为 4.33 和 4.34 倍。有必要在其他人群中进行复制。
