Lam Megan, Lai Charis, Almuhanna Nouf, Alhusayen Raed
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Faculty of Science, University of Western Ontario, London, ON, Canada.
Pediatr Dermatol. 2020 Nov;37(6):1044-1050. doi: 10.1111/pde.14326. Epub 2020 Sep 6.
Hidradenitis suppurativa (HS), characterized by inflammatory nodules, sinus tracts, and abscesses, has been linked to several factors, including immune dysfunction and obesity, which are thought to contribute to its development. Several follicular disorders have also been associated with Down syndrome (DS), a common chromosomal disorder, including HS, although studies on this topic are limited.
To characterize HS in Down syndrome patients and to further examine the association between HS and DS compared to HS patients without DS.
We systematically searched MEDLINE, Embase, Web of Science, and CENTRAL electronic databases from their dates of conception to February 2020. Random-effects meta-analyses were performed analyzing (a) HS characteristics between DS and non-DS participants, and (b) prevalence or association between HS and DS compared to non-DS individuals.
Twelve studies were included in this systematic review, with a total of 358 participants presenting with both HS and DS. Pooled analysis of mean differences between DS and non-DS participants presenting with HS found a significantly younger age of HS symptom onset for DS patients (-6.24; 95% CI, -10.01--2.24). A meta-analysis examining the association between HS and DS found a significantly increased likelihood of HS in DS patients (OR 9.61; 95% CI, 5.70-16.20).
Our findings suggest an association between HS and DS, with DS patients suffering from an earlier onset of HS symptoms compared to non-DS patients.
化脓性汗腺炎（HS）以炎性结节、窦道和脓肿为特征，与多种因素有关，包括免疫功能障碍和肥胖，这些因素被认为促使其发病。几种毛囊疾病也与常见的染色体疾病唐氏综合征（DS）有关，包括HS，不过关于这一主题的研究有限。
描述唐氏综合征患者的HS特征，并与非唐氏综合征的HS患者相比，进一步研究HS与DS之间的关联。
我们系统检索了MEDLINE、Embase、科学网和CENTRAL电子数据库，检索时间从其建库日期至2020年2月。进行随机效应荟萃分析，分析（a）唐氏综合征和非唐氏综合征参与者之间的HS特征，以及（b）与非唐氏综合征个体相比，HS与DS之间的患病率或关联性。
本系统评价纳入了12项研究，共有358名同时患有HS和DS的参与者。对患有HS的唐氏综合征和非唐氏综合征参与者之间的平均差异进行汇总分析发现，唐氏综合征患者HS症状出现的年龄明显更小（-6.24；95%CI，-10.01--2.24）。一项检验HS与DS之间关联的荟萃分析发现，唐氏综合征患者患HS的可能性显著增加（OR 9.61；95%CI，5.70-16.20）。
我们的研究结果表明HS与DS之间存在关联，与非唐氏综合征患者相比，唐氏综合征患者HS症状出现得更早。
