Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Dermatology. 2021;237(5):740-747. doi: 10.1159/000514582. Epub 2021 Mar 26.
Several studies report a high prevalence of inflammatory arthritis among hidradenitis suppurativa (HS) patients.
To study the association between HS and inflammatory arthritis.
The systematic review and meta-analysis were performed according to the PRISMA guidelines to identify the association between HS and inflammatory arthritis, spondyloarthritis, ankylosing spondylitis (AS), and rheumatoid arthritis (RA).
Seven studies were entered in the analysis, with 200,361 HS patients and 385,599 controls. Pooled analysis illustrated a significantly increased risk of inflammatory arthritis in HS patients compared to controls (odds ratio [OR] 3.44; 95% confidence interval [CI] 1.92-6.17). There was also a statistically significant association between HS and spondyloarthritis (OR 2.10; 95% CI 1.40-3.15), and between HS and AS (OR 1.89; 95% CI 1.14-3.12). Moreover, pooled analysis showed a statistically significant association between HS and RA (OR 1.96; 95% CI 1.28-2.98).
Our findings show that HS patients have a 3-fold increased risk of developing inflammatory arthritis. HS patients are specifically at a higher risk for spondyloarthritis, its subtype AS, and RA.
多项研究报告称，在患有化脓性汗腺炎（HS）的患者中，炎症性关节炎的患病率很高。
研究 HS 与炎症性关节炎之间的关联。
根据 PRISMA 指南进行系统评价和荟萃分析，以确定 HS 与炎症性关节炎、脊柱关节炎、强直性脊柱炎（AS）和类风湿关节炎（RA）之间的关联。
共有 7 项研究纳入分析，纳入了 200361 名 HS 患者和 385599 名对照。汇总分析表明，与对照组相比，HS 患者发生炎症性关节炎的风险显著增加（优势比 [OR] 3.44；95%置信区间 [CI] 1.92-6.17）。HS 与脊柱关节炎（OR 2.10；95% CI 1.40-3.15）和 AS（OR 1.89；95% CI 1.14-3.12）之间也存在统计学显著关联。此外，汇总分析显示 HS 与 RA（OR 1.96；95% CI 1.28-2.98）之间存在统计学显著关联。
我们的研究结果表明，HS 患者发生炎症性关节炎的风险增加了 3 倍。HS 患者患脊柱关节炎、AS 及其亚型和 RA 的风险更高。
