Zhang Lu, Gui Xin-Jing, Meng Fei, Xie Meng-di, Yao Jing, Hao Xiao-Jia, Yan Bin, Chen Hong-Yan, Chen Shu-He, Zhao Chun, An Ya-Ting, Yang Xin-Jian, Li Xue-Lin, Liu Rui-Xin
Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China the Level Three Laboratory of Chinese Traditional Medical Preparation of State Administration of Traditional Chinese Medicine Zhengzhou 450000, China Henan Province Engineering Research Center of Clinical Application Modernization of Traditional Chinese Medicine Pieces Zhengzhou 450000, China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Henan University of Chinese Medicine Zhengzhou 450000, China.
Henan University of Chinese Medicine Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3681-3688. doi: 10.19540/j.cnki.cjcmm.20200424.307.
This study aims to explore the change laws of water absorption in Chinese herbal pieces and establish the prediction model of relative density for Chinese medicine compound decoction. Firstly, fitted equations of water absorption and decocting time was established by observing the change laws of water absorption in 36 kinds of Chinese herbal pieces in 12 groups(according to the drug-parts) with decocting time. The r value of the mineral group and other type group was 0.691 2 and 0.663 3, respectively. The r value of the remaining 10 groups was 0.802 2-0.925 4. All P values were less than 0.05(n=21). The formula of the amount of water added was optimized by combining the fitted equations with determined water absorption, and the liquid yield could be controlled in a range of 100%±10%. Secondly, it was determined that the liquid density tester could be used for the rapid determination of relative density of Chinese medicine decoction after methodological study and comparison with the pycnometer method. The linear regression equation between the corrected relative density(y) and extraction ratio(%, x) was built by measuring and analyzing the related parameters such as liquid yield, relative density and extraction ratio in 46 kinds of Chinese herbal pieces. The established equation was y=0.041 3x+1.003 7, r=0.930 9(P <0.01, n=46), with linear range of 1.94%-65.75%. Based on this, the prototype model for predicting relative density of Chinese medicine decoction was established, and the relative densities of 8 Chinese medicine decoctions were within the prediction interval of this model in verification. This study lays a foundation for database construction of Chinese medicine decoction, implementation of personalized decocting mode and rapid quality control of Chinese medicine decoction.
本研究旨在探索中药饮片吸水率的变化规律，建立中药复方汤剂相对密度预测模型。首先，通过观察12组（按药物部位）36种中药饮片吸水率随煎煮时间的变化规律，建立了吸水率与煎煮时间的拟合方程。矿物类组和其他类组的r值分别为0.691 2和0.663 3。其余10组的r值为0.802 2 - 0.925 4。所有P值均小于0.05（n = 21）。将拟合方程与测定的吸水率相结合，优化加水量公式，可将出液量控制在100%±10%范围内。其次，经方法学研究并与比重瓶法比较，确定液体密度测定仪可用于快速测定中药汤剂的相对密度。通过测定和分析46种中药饮片的出液量、相对密度和提取率等相关参数，建立了校正相对密度（y）与提取率（%，x）之间的线性回归方程。所建立的方程为y = 0.041 3x + 1.003 7，r = 0.930 9（P <0.01，n = 46），线性范围为1.94% - 65.75%。在此基础上，建立了中药汤剂相对密度预测原型模型，8种中药汤剂的相对密度在验证中均处于该模型的预测区间内。本研究为中药汤剂数据库建设、个性化煎煮模式实施及中药汤剂快速质量控制奠定了基础。
