Zhang Wen, Zhu Ya-di, Zhang Qi-Yao, Ma Li-Juan, Yang Ling, Guo Wen-Zhi, Ge Guang-Bo
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou Key Laboratory of Organ Transplantation Technology and Application Engineering Zhengzhou 450001, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(16):3759-3769. doi: 10.19540/j.cnki.cjcmm.20200513.601.
Schisandra is the mature fruit of Schisandra chinensis(known as "north Schisandra") or S. shenanthera(known as "south Schisandra"). S. chinensis contains a variety of lignans, volatile oils, polysaccharides, organic acids and other chemical constituents; among them, lignans are recognized as the characteristic active components. Clinical studies have found that Schisandra and Schisandra-related products have a better effect in the prevention and treatment of viral hepatitis, drug-induced liver injury, liver cirrhosis, liver failure and other liver diseases. Modern pharmacological studies have demonstrated that Schisandra has a variety of pharmacological activities, such as anti-inflammation, antioxidation, anticancer, regulation of nuclear receptor, antivirus, regulation of cytochrome P450 enzyme, inhibition of liver cell apoptosis and promotion of liver regeneration. This paper reviews the studies about the applications and mechanism of Schisandra in the prevention and treatment of liver diseases, in the expectation of providing guidance for the development of hepatoprotective drugs from Schisandra and the clinical applications of Schisandra-related products.
五味子是五味子科植物五味子（习称“北五味子”）或华中五味子（习称“南五味子”）的干燥成熟果实。五味子含有多种木脂素、挥发油、多糖、有机酸等化学成分；其中，木脂素被认为是其特征性活性成分。临床研究发现，五味子及其相关制品在病毒性肝炎、药物性肝损伤、肝硬化、肝衰竭等肝脏疾病的防治方面具有较好疗效。现代药理研究表明，五味子具有多种药理活性，如抗炎、抗氧化、抗癌、调节核受体、抗病毒、调节细胞色素P450酶、抑制肝细胞凋亡及促进肝再生等。本文综述了五味子在肝脏疾病防治中的应用及作用机制的研究，以期为五味子保肝药物的开发及五味子相关制品的临床应用提供指导。
