Zhang Ming-Xiao, Huang Guo-Ying, Bai Yu-Qi, Li Hua, Yang Bin
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
Zhongguo Zhong Yao Za Zhi. 2021 Mar;46(5):1017-1025. doi: 10.19540/j.cnki.cjcmm.20201127.601.
Schisandrae has a long history of medicinal use in China. Domestic and foreign scholars have isolated a variety of chemical constituents from Schisandrae Sphenantherae Fructus and Schisandrae Chinensis Fructus, including lignans, volatile oils, polysaccharides, triterpenoids, organic acids, amino acids and so on. Pharmacological studies have shown that their alcohol extracts, water extracts, lignan monomers and polysaccharides could protect liver injury and reduce enzyme ability by a variety of hepatoprotective effects such as enzyme reducing, liver protecting, and antioxidant effect. In this paper, the researches on the chemical composition, hepatoprotective effect and pharmacokinetics of Schisandrae Sphenantherae Fructus and Schisandrae Chinensis Fructus in the past forty years were systematically collated, in order to provide useful enlightenment for the clinical application and new drug development of Schisandrae Sphenantherae Fructus and Schisandrae Chinensis Fructus in liver protection.
五味子在中国有着悠久的药用历史。国内外学者已从南五味子和五味子中分离出多种化学成分，包括木脂素、挥发油、多糖、三萜类、有机酸、氨基酸等。药理研究表明，它们的醇提取物、水提取物、木脂素单体和多糖可通过多种保肝作用，如降酶、保肝和抗氧化作用来保护肝损伤并降低酶活性。本文系统整理了近四十年来南五味子和五味子在化学成分、保肝作用及药代动力学方面的研究，以期为南五味子和五味子在肝脏保护方面的临床应用及新药开发提供有益启示。
