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西班牙某地区葡萄膜炎的流行病学:患病率与病因

Epidemiology of Uveitis in a Spanish Region: Prevalence and Etiology.

作者信息

García-Aparicio A, Alonso Martín L, López Lancho R, Quirós Zamorano R, Del Olmo Perez L, Sánchez Fernández S, Otón T, Jiménez Escribano R, González Del Valle F, Muñoz-Fernández S

机构信息

Department of Rheumatology, Hospital Virgen De La Salud, Complejo Hospitalario De Toledo, Toledo, Spain.

Department of Ophthalmology, Hospital Virgen De La Salud, Complejo Hospitalario De Toledo, Toledo, Spain.

出版信息

Ophthalmic Epidemiol. 2021 Jun;28(3):227-236. doi: 10.1080/09286586.2020.1815802. Epub 2020 Sep 7.

Abstract

OBJECTIVE

To estimate the prevalence of uveitis and to describe its etiologic and anatomical patterns based on a population study carried out in a Spanish region.

MATERIAL AND METHODS

A cross-sectional, descriptive, population-based multicenter study was conducted. The selection criteria consisted of having a diagnosis of uveitis. All data were collected from existing information in medical records.Clinical information was collected in all cases that had a diagnosis of uveitis, regardless of its etiology, in participating centers from the date of the study to the end of the following year. All patients underwent a complete ophthalmological examination, which included assessment of their visual acuity, biomicroscopy, applanation tonometry, and indirect ophthalmoscopy.

RESULTS

During the study, 389 cases of uveitis were registered. The prevalence was 58.7 (95% confidence interval [CI] 53.0-64.9). The mean age was 47.0 ± 20.6 years and 57.8% were women. The most prevalent anatomical pattern was anterior uveitis (54.2; 95% CI 48.1-60.8). For adults, the idiopathic group constituted the highest prevalence (31.7; 95% CI: 27.1-36.9), while autoimmune etiology was most frequent for children (10.6; 95% CI: 5.8-17.7).

CONCLUSION

The results of this population-based study offer a representative estimate of the magnitude of uveitis in this area of Spain.

摘要

目的

基于在西班牙一个地区开展的一项人群研究,评估葡萄膜炎的患病率,并描述其病因和解剖学模式。

材料与方法

进行了一项横断面、描述性、基于人群的多中心研究。选择标准为患有葡萄膜炎的诊断。所有数据均从病历中的现有信息收集。从研究开始至次年年底,在参与研究的中心,对所有诊断为葡萄膜炎的病例(无论其病因如何)收集临床信息。所有患者均接受了全面的眼科检查,包括视力评估、生物显微镜检查、压平眼压测量和间接检眼镜检查。

结果

在研究期间,共登记了389例葡萄膜炎病例。患病率为58.7(95%置信区间[CI]53.0 - 64.9)。平均年龄为47.0±20.6岁,女性占57.8%。最常见的解剖学模式是前葡萄膜炎(54.2;95%CI 48.1 - 60.8)。对于成年人,特发性组患病率最高(31.7;95%CI:27.1 - 36.9),而儿童中自身免疫性病因最为常见(10.6;95%CI:5.8 - 17.7)。

结论

这项基于人群的研究结果提供了西班牙该地区葡萄膜炎发病规模的代表性估计。

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