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[养老院中由8型人腺病毒引起的流行性角结膜炎暴发。]

[Outbreak of epidemic keratoconjunctivitis caused by human adenovirus serotype 8 in a nursing home.].

作者信息

Esparcia Rodríguez Óscar, Gómez Martínez Angélica, Martínez Nieto María José, Salmerón Cifuentes María Soledad, Rodolfo Saavedra Remedios, de la Cruz de Julián Isidro

机构信息

Sección de Epidemiología. Delegación Provincial de Sanidad. Albacete. España.

Quirónsalud. Residencia de mayores Alcabala. Albacete. España.

出版信息

Rev Esp Salud Publica. 2020 Sep 8;94:e202009100.

Abstract

OBJECTIVE

Ocular infections caused by human adenovirus are highly contagious and can cause outbreaks, especially in nursing homes. In this work, we describe the epidemiological and analytical research as well as the control measures carried out for a conjunctivitis outbreak.

METHODS

Descriptive epidemiological study. Cases with a symptom onset date prior to oficial communication were analyzed retrospectively. The rest was analyzed prospectively. Conjunctival smears were collected for microbiological study. Virological analysis was performed by detecting adenovirus by PCR and genotyping. A data questionnaire that collected clinical and epidemiological information was designed. Possible risk factors associated with infection were studied by calculating the Odds Ratio.

RESULTS

On June 11, 2019, the Epidemiological Surveillance Section of the Provincial Health Department of Albacete was notified of the existence of a large number of cases of conjunctivitis in a geriatric center. 54 cases were declared: 43 internal residents, 3 day center assistants and 8 workers. Attack rates were 35.8%, 12.5% and 8.4% respectively. Three risk factors were associated with the disease: patient´s lack of autonomy, being a resident at the nursing home and having their room assigned on the first floor. Human adenovirus serotype 8 was detected in the patients' samples.

CONCLUSIONS

A high attack rate was observed in internal residents and the disease was associated with patient´s lack of autonomy and having their room assigned on the first floor of the nursing home. The outbreak was caused by human adenovirus serotype 8.

摘要

目的

人类腺病毒引起的眼部感染具有高度传染性,可导致疫情爆发,尤其是在疗养院。在这项工作中,我们描述了针对一次结膜炎疫情所开展的流行病学和分析研究以及控制措施。

方法

描述性流行病学研究。对在官方通报之前出现症状的病例进行回顾性分析。其余病例进行前瞻性分析。采集结膜涂片进行微生物学研究。通过聚合酶链反应(PCR)检测腺病毒并进行基因分型来开展病毒学分析。设计了一份收集临床和流行病学信息的数据问卷。通过计算优势比来研究与感染相关的可能风险因素。

结果

2019年6月11日,阿尔巴塞特省卫生部门的流行病学监测科接到通知,一家老年护理中心存在大量结膜炎病例。共报告54例:43例为机构内居住者,3例为日间护理中心工作人员,8例为工作人员。罹患率分别为35.8%、12.5%和8.4%。有三个风险因素与该病相关:患者缺乏自理能力、居住在疗养院以及房间分配在一楼。在患者样本中检测到人类腺病毒8型。

结论

观察到机构内居住者的罹患率较高,且该病与患者缺乏自理能力以及房间分配在疗养院一楼有关。此次疫情由人类腺病毒8型引起。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7830/11582866/e1accb27eaf7/1135-5727-resp-94-e202009100-g003.jpg

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