Lei Zhenqiang, Zhu Zhen, Wang Bai Ma Ci, Mei Hong, Li Hong, Ga Dan Zeng Gong, Jie Guo, Chi Mi Ma Bu, Zhang Sheng, Ma Chaofeng, Xu Wenbo
School of Public Health, Shaanxi University of Chinese Medicine, Xianyang city, Shaanxi province, People's Republic of China.
WHO WPRO Regional Reference Measles/Rubella laboratory and Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing City, People's Republic of China.
PLoS One. 2017 Sep 15;12(9):e0185048. doi: 10.1371/journal.pone.0185048. eCollection 2017.
From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. This is the first report of a HAdV-8 associated EKC outbreak in mainland of China, and the results of this study are expected to provide support for future research into HAdV-8 in China.
2016年4月至11月，中国西藏自治区的中小学先后发生了两起流行性角结膜炎（EKC）疫情，共报告了197例临床诊断病例。实时PCR分析证实，人类腺病毒（HAdV）感染与这些疫情有关。进一步基于五邻体基底、六邻体和纤维基因进行序列测定和系统发育分析的研究表明，属于D种的人类8型腺病毒（HAdV-8）是此次疫情的病原体。这是中国大陆首次关于HAdV-8相关EKC疫情的报告，本研究结果有望为中国未来对HAdV-8的研究提供支持。
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