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制定通用路线图,以加强对动物传染病和人畜共患病的全球研究的战略协调。

Construction of generic roadmaps for the strategic coordination of global research into infectious diseases of animals and zoonoses.

机构信息

The Roslin Institute at The University of Edinburgh, Edinburgh, UK.

AnimalhealthEurope, Brussels, Belgium.

出版信息

Transbound Emerg Dis. 2021 May;68(3):1513-1520. doi: 10.1111/tbed.13821. Epub 2020 Sep 19.

DOI:10.1111/tbed.13821
PMID:32896967
Abstract

The Strategic Alliance for Research into Infectious Diseases of Animals and Zoonoses (STAR-IDAZ) International Research Consortium (IRC) coordinates global animal health research to accelerate delivery of disease control tools and strategies. With this vision, STAR-IDAZ IRC has constructed four generic research roadmaps for the development of candidate vaccines, diagnostic tests, therapeutics and control strategies for animal diseases. The roadmaps for vaccines, diagnostic tests and therapeutics lead towards a desired target product profile (TPP). These interactive roadmaps describe the building blocks and for each the key research questions, dependencies, challenges and possible solution routes to identify the basic research needed for translation to the TPP. The control strategies roadmap encompasses the vaccine, diagnostic tests, and therapeutic roadmaps within a wider framework focusing on the inter-dependence of multiple tools and knowledge to control diseases for the benefit of animal and human health. The roadmaps are now being completed for specific diseases and complemented by state-of-the-art information on relevant projects and publications to ensure that the necessary research gaps are addressed for selected priority diseases.

摘要

动物传染病和人畜共患病研究战略联盟(STAR-IDAZ)国际研究联盟(IRC)协调全球动物健康研究,以加速疾病控制工具和策略的交付。基于这一愿景,STAR-IDAZ IRC 为候选疫苗、诊断测试、治疗剂和动物疾病控制策略的开发构建了四个通用研究路线图。疫苗、诊断测试和治疗剂路线图朝着理想的目标产品概况(TPP)发展。这些互动路线图描述了构建模块,以及每个关键研究问题、依赖性、挑战和可能的解决方案途径,以确定将基本研究转化为 TPP 所需的基本研究。控制策略路线图将疫苗、诊断测试和治疗剂路线图纳入一个更广泛的框架内,重点关注多种工具和知识相互依存,以控制疾病,造福动物和人类健康。这些路线图目前正在针对特定疾病进行编制,并补充了相关项目和出版物的最新信息,以确保针对选定优先疾病解决必要的研究差距。

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