Wu Shuping, Gao Yinghui, Qian Xiaoshun, Zhao Libo, Xu Hu, Xu Weihao, Kong Xiaoxuan, Yang Yang, Che Hebin, Wang YaBin, Yuan Xina, Liu Lin
Department of Respiratory Disease, Second Medical Center of General Hospital of PLA, Beijing 100853, China.
National Clinical Research Center for Geriatric Diseases, General Hospital of PLA, Beijing 100853, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2020 May 30;40(5):703-707. doi: 10.12122/j.issn.1673-4254.2020.05.14.
To investigate the correlation between the severity of obstructive sleep apnea syndrome (OSAS) and red cell distribution width (RDW) in elderly patients.
A cross-sectional study was conducted among 311 elderly patients diagnosed with OSAS in the snoring clinic between January, 2015 and October, 2016 and 120 healthy controls without OSAS from physical examination populations in the General Hospital of PLA. The subjects were divided into control group with apnea-hypopnea index (AHI) <5 (=120), mild OSAS group (AHI of 5.0-14.9; =90), moderate OSAS group (AHI of 15.0-29.9; =113) and severe OSAS group (AHI ≥ 30; =108). The clinical characteristics and the results of polysomnography, routine blood tests and biochemical tests of the subjects were collected. Multiple linear regression analysis was used to examine the correlation between OSAS severity and RDW.
The levels of RDW and triglyceride were significantly higher in severe OSAS group than in the other groups ( < 0.01). The levels of fasting blood glucose and body mass index were significantly higher in severe and moderate OSAS groups than in mild OSAS group and control group ( < 0.05 or < 0.01). Multiple linear regression analysis showed that AHI was positively correlated with body mass index (β=0.111, =0.032) and RDW (β=0.106, =0.029). The area under ROC curve of RDW for predicting the severity of OSAS was 0.687 (=0.0001).
The RDW increases as OSAS worsens and may serve as a potential marker for evaluating the severity of OSAS.
探讨老年患者阻塞性睡眠呼吸暂停综合征（OSAS）严重程度与红细胞分布宽度（RDW）之间的相关性。
对2015年1月至2016年10月在打鼾门诊确诊为OSAS的311例老年患者及解放军总医院体检人群中120例无OSAS的健康对照者进行横断面研究。将受试者分为呼吸暂停低通气指数（AHI）<5的对照组（n = 120）、轻度OSAS组（AHI为5.0 - 14.9；n = 90）、中度OSAS组（AHI为15.0 - 29.9；n = 113）和重度OSAS组（AHI≥30；n = 108）。收集受试者的临床特征、多导睡眠图结果、血常规及生化检查结果。采用多元线性回归分析探讨OSAS严重程度与RDW之间的相关性。
重度OSAS组的RDW和甘油三酯水平显著高于其他组（P < 0.01）。重度和中度OSAS组的空腹血糖和体重指数水平显著高于轻度OSAS组和对照组（P < 0.05或P < 0.01）。多元线性回归分析显示，AHI与体重指数（β = 0.111，P = 0.
