From the Complexo Hospitalario Universitario de Pontevedra (Parafita-Fernandez), Pontevedra, Clinica Oftalmológica Dr. Parafita (Parafita-Fernandez), Ribeira, Clinica Rementería (Gros-Otero, García-González), Universidad CEU San Pablo (Gros-Otero), Universidad Europea (Villa-Collar), Clínica Novovisión (García-González, Teus), Hospital Universitario Principe de Asturias, University of Alcala de Henares (Teus), Madrid, Spain.
J Cataract Refract Surg. 2020 Sep;46(9):1278-1283. doi: 10.1097/j.jcrs.0000000000000255.
To assess the relevance of the homogeneity of femtosecond laser flap thickness regarding induction of higher-order aberrations (HOAs).
Clínica Rementería & Clínica Novovisión, Madrid, Spain.
Prospective observational study.
Two hundred thirty-one patients underwent in situ keratomileusis using 5 different femtosecond lasers. The flap thicknesses were measured using anterior segment optical coherence tomography 3 months postoperatively. The same masked observer measured 6 symmetrical points nasally and temporally 1.0 mm, 2.0 mm, and 3.0 mm from the center of the flap in each case. HOAs induced in the cornea were measured using tomography.
Positive and significant correlations were found between HOA induction and the flap thickness heterogeneity 3.0 mm from the center of the flap. Pearson correlation coefficients for the induction of HOAs were third-order 0.17112 (P = .0224), fourth-order 0.22474 (P = .0026), fifth-order 0.16449 (P = .0282), coma-like 0.17370 (P = .0204), and total HOAs 0.18182 (P = .0151).
The amount of flap-thickness heterogeneity at 3.0 mm from the center of the flap created using femtosecond lasers was correlated with the magnitude of the HOAs induced.
评估飞秒激光瓣厚度的均匀性与高阶像差（HOAs）诱导之间的相关性。
马德里的 Clínica Rementería 和 Clínica Novovisión。
前瞻性观察研究。
231 例患者接受了 5 种不同飞秒激光的原位角膜磨镶术。术后 3 个月，使用眼前节光学相干断层扫描测量瓣厚度。同一位盲法观察者测量了每个病例中心 1.0mm、2.0mm 和 3.0mm 处鼻侧和颞侧 6 个对称点的厚度。使用断层扫描测量角膜诱导的 HOAs。
发现角膜诱导的 HOAs 与瓣厚度 3.0mm 处的不均匀性之间存在正相关和显著相关性。HOAs 诱导的 Pearson 相关系数为三阶 0.17112（P =.0224），四阶 0.22474（P =.0026），五阶 0.16449（P =.0282），彗差样 0.17370（P =.0204）和总 HOAs 0.18182（P =.0151）。
飞秒激光制作的瓣厚度在离瓣中心 3.0mm 处的不均匀性与诱导的 HOAs 大小相关。
