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慢性钙化性胰腺炎:印度北部的临床概况

Chronic calcific pancreatitis: clinical profile in northern India.

作者信息

Rai R R, Acharya S K, Nundy S, Vashisht S, Tandon R K

机构信息

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.

出版信息

Gastroenterol Jpn. 1988 Apr;23(2):195-200. doi: 10.1007/BF02799032.

Abstract

Twenty three patients with chronic calcific pancreatitis of the tropics in Northern India were prospectively studied. All had pancreatic calcification and ERCP changes typical of chronic pancreatitis, the most predominant being ductal dilatation which was detected in all patients by both ERCP and by ultrasonography. Pain was present in 19 (83%) patients and diabetes in 11 (48%) patients. Exocrine pancreatic dysfunction was uncommon, steatorrhoea being present in only 9% of patients. Ten of the 11 patients with diabetes required insulin for control and one case was able to be controlled by an oral antidiabetic agent. Two patients developed ketoacidosis during acute episodes of pancreatitis, 3 patients had peripheral neuropathy and one patient had visual changes. Recurrent severe pain was the reason for operation in 7 patients. All had a lateral pancreaticojejunostomy. In order to obtain an objective assessment of pain, a scoring system was developed to grade its severity according to its intensity, frequency and consequences. Six patients who preoperatively had a pain score of 15 or more (out of a maximum score of 24) attained significant relief after the surgery. We feel this scoring system may provide an easy objective assessment of pain in the subsequent follow-up of these patients.

摘要

对印度北部热带地区的23例慢性钙化性胰腺炎患者进行了前瞻性研究。所有患者均有胰腺钙化及慢性胰腺炎典型的内镜逆行胰胆管造影(ERCP)改变,最主要的是导管扩张,通过ERCP和超声检查在所有患者中均能检测到。19例(83%)患者有疼痛,11例(48%)患者有糖尿病。胰腺外分泌功能障碍不常见,仅9%的患者有脂肪泻。11例糖尿病患者中有10例需要胰岛素控制,1例能够通过口服降糖药控制。2例患者在胰腺炎急性发作期间发生酮症酸中毒,3例患者有周围神经病变,1例患者有视力改变。7例患者因反复严重疼痛接受手术。所有患者均行胰体尾侧-空肠吻合术。为了对疼痛进行客观评估,制定了一个评分系统,根据疼痛的强度、频率和后果对其严重程度进行分级。术前疼痛评分为15分或更高(满分24分)的6例患者术后疼痛明显缓解。我们认为该评分系统可能为这些患者后续随访中的疼痛提供一种简单的客观评估方法。

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